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20.04.2024

Weight loss by supplementing with Immortality Herb | Losing fat, maintaining lean body mass

Healthy people with excess body fat can lose weight if they take 2 capsules with Gynostemma pentaphyllum extract every day. This plant is also called Immortality Herb. An advantage of losing weight with Gynostemma pentaphyllum is that it is not at the expense of your muscle mass.

Study
Australian researchers from the private RDC Clinical divided 117 obese [their BMI ranged from 25 to 35] but healthy subjects into 2 groups. For 16 weeks, the subjects in one group took a placebo every day, while the subjects in the second group took 2 capsules each day, each containing 225 milligrams of Gynostemma pentaphyllum extract.

The extract the researchers used was developed by the BTC Corporation. It is marketed as ActivAMP. BTC works closely with Gencor - and Gencor paid for the study.

Results
The test subjects in the ActivAMP group lost an average of more than a kilo of their body weight. That kilo consisted almost entirely of body fat - and therefore not of lean body mass.

Click on the figures below for a larger version.

In the blood of the test subjects in the ActivAMP group, the concentration of TNF-alpha dropped from 9.3 to 8.2 picograms per milliliter. The researchers don't know how to interpret that.

Fat tissue produces less TNF-alpha as it is healthier and fewer immune cells are breaking down fat cells. Perhaps ActivAMP made the fat cells function better.

Mechanism
"The therapeutic activities of Gynostemma pentaphyllum are proposed to be related to the AMP-activated protein kinase (AMPK) - activating effects of the dammarane-type saponins", write the researchers.

"The mechanism of action of dammaranes, which involves the activation (phosphorylation) of AMPK, mimics the effects of physical exercise, including an up-regulation of autophagy with increased mitochondrial neogenesis and glucose transporter-4 expression, as well as a subsequent improvement of insulin sensitivity."

Source:
J Hum Nutr Diet. 2022 Jun;35(3):583-9.

More:
Lose weight without dieting with Gynostemma pentaphyllum 20.06.2014

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