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16.11.2021


Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity

If older men with a low testosterone level take 1200 milligrams of D-chiro-inositol daily, their testosterone level rises, their fat mass decreases, their estradiol level drops and their muscle strength and insulin sensitivity increase.


Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity


Study
As long as the supplement industry has been marketing products that are supposed to increase testosterone levels, hormone-modulating supplements containing forms of inositol have been on the shelves. Whether supplementation with D-chiro-inositol actually increases testosterone levels, however, had never been investigated.

For this reason, Italian researchers from the Expert Group on Inositol in Basic and Clinical Research decided to conduct an experiment in which 10 men aged 65-75 years with low testosterone levels took two pills each day, each containing 600 milligrams of D-chiro-inositol, for 30 days.

There was no control group.

D-Chiro-Inositol
D-Chiro-Inositol is a major metabolite of myo-inositol. The body manufactures D-chiro-inositol, but D-chiro-inositol is also found in buckwheat, pumpkin and soy lecithins.

Click on the figure below for a larger version.


Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity


In cells, forms of inositol transport important molecules, which for example enable receptors to function.

Results
During the supplementation period, the subjects' testosterone levels increased by 18 percent. This was at the expense of the estradiol level, which fell by 19 percent.

In addition, the men lost over a kilo of body weight. Given the decrease in the waist of the men, this was mainly body fat. This change in body composition may have been the result of increased insulin sensitivity.

Click on the table below for a larger version.


Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity


Two capsules of D-chiro-inositol per day: more testosterone, less estradiol, less body fat and greater insulin sensitivity
During the supplementation, the men's sexual functioning and the strength with which they could squeeze a dynamometer improved.

Conclusion
"In this open-label pilot study, older men with low-normal testosterone levels receiving D-chiro-inositol showed improved glycaemic and hormonal profiles, without apparent adverse effects over the 30-day study duration", the Italians write.

"If our results will be confirmed in stronger randomised and placebo-controlled trials, D-chiro-inositol could be considered as a suitable agent to increase testosterone levels and improve health outcomes in older men with physiological hypogonadism."

Source:
Basic and Clinical Andrology (2021) 31:28.

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