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07.02.2024

Supplementing with berberine makes the almost-diabetic healthier and slimmer

Healthy people with just acceptable glucose levels, who do not yet have diabetes but may be in the process of developing it, become healthier by supplementing with berberine. Moreover, they become slimmer.

Study
Italian researchers, affiliated with the university Pavia and the manufacturer Indena, experimented with 49 obese adults with high glucose levels. Strictly speaking, the test subjects did not yet have diabetes.

The researchers gave half of the test subjects a placebo every day for 2 months. The other half received a tablet containing a berberine supplement from Indena every day, just before lunch and just before dinner. Each tablet contained 550 milligrams of a phytosome preparation of berberine, good for 188 milligrams of berberine. You can see the chemical structure of berberine above.

If active substances are packaged in phytosomes, the body can absorb them better. The extract the researchers used is marketed as Berberine Phytosome.

Results
In the supplementation group, the way the body handles glucose improved. The amount of glucose in the blood early in the morning decreased, as did the insulin level. The HOMA-IR, a measure of the degree of insulin resistance, decreased by 26 percent.

Click on the table for a larger version.

At the same time, cholesterol levels improved and waist size and fat mass decreased by 2 centimeters and 2 kilos, respectively. The fat-free mass remained constant.

These effects were statistically significant - not only within the supplementation group, but also when the researchers compared them to the changes in the placebo group. [Table]

Conclusion
"The administration of Berberine Phytosome did not result in side effects, supporting its potential use as a natural alternative to pharmacological therapies in the case of impaired fasting blood glucose", write the researchers.

"The results of this study are encouraging."

Source:
Eur Rev Med Pharmacol Sci. 2023 Jul;27(14):6718-27.

More:
Take berberine, live 80 percent longer | Animal data 09.05.2021

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