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03.11.2023

Brazilian propolis improves immune system of Covid-19 patients

If you have Covid-19, the virus infection opens the door to other germs. This means you run the risk of what doctors call 'secondary infections'. Supplementation with Brazilian propolis can prevent this, according to a trial published in Scientific Reports.

Study
Brazilian doctors affiliated with the Hospital Sao Rafael had discovered during the first Covid wave that supplementation with Brazilian propolis allowed Covid patients to be discharged from the hospital more quickly. In the second half of 2021, during the third Covid wave, the doctors repeated their experiment.

The Brazilians gave 90 Covid patients, who had just been admitted to their hospital, a placebo every day for 10 days. A group of 98 other Covid patients received 900 milligrams of the Brazilian propolis extract EPP-AF every day for 10 days. The researchers used a product from Apis Flora, which is marketed as Propomax.

Apis Flora did not sponsor the study.

Results
The subjects who received Brazilian propolis were out of the hospital faster than the subjects in the placebo group. However, the difference was not statistically significant. Brazilian propolis shortened the stay by almost twenty percent of test subjects who had not been vaccinated against Covid-19. However, that difference was also not statistically significant.

The effect of supplementation on secondary infections was significant. In the placebo group, these occurred in 18.9 percent of the subjects. In the experimental group this happened to 6.1 percent.

Click on the figures below for a larger version.

"Green propolis-derived compounds may generate negative feedback in the expression of transmembrane serine protease 2 (TMPRSS2), which engages in the activation of spike protein of viruses", write the Brazilians. "It also interferes with angiotensin-converting enzyme 2 (ACE2) anchoring, therefore limiting the entry of virus in a cell."

"Also, there is evidence that some propolis compounds are capable of reducing the activation of p21-activated kinase-1 (PAK1), overexpressed in the lungs and an important target used by viruses to both shield themselves from adaptive immunological responses and locally stimulate an exaggerated infammatory response."

More coming soon.

Source:
Sci Rep. 2023 Oct 27;13(1):18405.

More:
The protective role of Brazilian propolis in chronic kidney disease 08.06.2023
Fat loss as a result of Brazilian propolis supplementation 05.02.2023
Green Propolis gets covid patient discharged from hospital sooner 22.08.2021
Supplement with Brazilian propolis makes deadly viruses less dangerous 18.08.2021

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