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08.06.2023


The protective role of Brazilian propolis in chronic kidney disease

If bad genes, diabetes or lifestyle factors are wreaking havoc on your kidneys, you may benefit from supplementing with Brazilian propolis. This is suggested by a small trial in which 500 milligrams of Brazilian propolis per day reduces the concentration of protein in the urine in patients with chronic kidney disease.


If bad genes, diabetes or lifestyle factors are wreaking havoc on your kidneys, you may benefit from supplementing with Brazilian propolis. This is suggested by a small trial in which 500 milligrams of Brazilian propolis per day reduces the concentration of protein in the urine in patients with chronic kidney disease.


Study
Brazilian nephrologists, affiliated with the University of Sao Paulo School of Medicine, experimented with 32 patients with chronic kidney disease. They divided the patients into 2 groups.

The subjects in one group received a placebo daily for 12 months. The subjects in the other group received 250 milligrams of Brazilian propolis twice a day. So the test subjects consumed 500 milligrams of Brazilian propolis every day. The researchers used Green Propolis EPP-AF, a supplement from Apis Flora. Apis Flora did not sponsor the study.

Results
The presence of relatively high protein in the urine indicates kidney damage. The medical term for this phenomenon is proteinuria. Nephrologists determine the degree of proteinuria by the urinary albumin-creatinine ratio [UACR].

Supplementation with Brazilian propolis reduced the the UACR of the test subjects. It should be noted that even after a year of supplementation, the UACR of both groups of test subjects was still in the red zone.

Click on the figures for a larger version.


The protective role of Brazilian propolis in chronic kidney disease


The protective role of Brazilian propolis in chronic kidney disease


The protective role of Brazilian propolis in chronic kidney disease


Mechanism
Inflammatory reactions play an important role in chronic kidney disease, which are driven in particular by the inflammatory protein MCP-1. In animal studies, interventions that block MCP-1 may slow the development of chronic kidney disease. [Biochem Biophys Res Commun. 2007 Sep 7;360(4):772-7.]

In the trial on which this post is based, there was a tendency for Brazilian propolis supplementation to reduce the concentration of MCP-1 in the urine.


The protective role of Brazilian propolis in chronic kidney disease


Source:
BMC Nephrol. 2019 Apr 25;20(1):140.

More:
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