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06.01.2025

Higher vitamin D levels, lower PSA

For many men with prostate problems or prostate cancer, PSA levels are a tell-tale sign. The faster and higher PSA levels rise, the bleaker the outlook. A small epidemiological study from India suggests that relatively high vitamin D levels slow the rise in PSA.

Study
Janvitha Reddy, a biochemist at the Sri Ramaswamy Memorial Institute of Science and Technology, published a study in 2024 involving 88 men with benign prostate hyperplasia. The men had urinary problems and had consulted a doctor.

Reddy determined the concentration of the protein prostate-specific antigen [PSA] in the blood of the study participants. PSA is released when prostate cancer cells divide. The more and the more often those cells divide, the higher the concentration of PSA.

Oncologists use the concentration of PSA in the blood of men as a marker for the risk of prostate cancer. For men who already have prostate cancer, PSA is a marker for the progression of the disease. In both cases, the higher the PSA, the worse the prospects.

Results
The older the men were, the higher their PSA. That is obvious. The concentration of PSA is higher in older men than in younger men.

Click on the figure below for a larger version.

Vitamin D had exactly the opposite effect. The higher the concentration of vitamin D in the blood, the lower the concentration of PSA.

Conclusion
"A total PSA screening tool can reflect the prostate health status of men and help identify the need for vitamin D supplementation, which can be implemented at the earliest", write the researchers.

"Hence, a routine biochemistry panel for screening prostate health in men should consider total PSA and vitamin D levels so that individuals deficient in vitamin D are identified and interventional strategies can be planned for their well-being."

Source:
Cureus. 2024 Dec 2;16(12):e74959.

More:
How a soya and vitamin D combination kills prostate cancer cells 10.03.2013

Archives:
Prevention & Survival of Cancer
Prostate Health
Vitamin D
Vitamins

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