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26.03.2024

Trigonelline as a natural anabolic agent - also for young people

We are becoming increasingly interested in the muscle-building properties of trigonelline, which we already wrote about the day before yesterday. Today we found and read a somewhat older patent in which trigonelline also enhanced anabolic processes and inhibited catabolic processes in young laboratory animals.

Patent
The patent we are talking about is in the name of DSM, a manufacturer of ingredients for functional foods and supplements. The European version of that patent was already filed in 2009. It is based on in vitro studies and animal studies that DSM must have conducted several years earlier.

A few days ago we mentioned a recent patent from Nestlé for the use of trigonelline in protein-rich products that are supposed to stimulate muscle growth. Nestlé also published a controversial study that showed that trigonelline had anabolic and longevity effects - but in which protein supplementation was not an issue.

Now that we know DSM's patent, we understand the Nestlé patent better. By adding the element of proteins, Nestlé tried to avoid DSM's patent.

Study
Nestlé's patent describes in vitro research in which trigonelline accelerates the development of young muscles by 36 percent. That's nice, but the animal studies described in the patent are even nicer. These concern female C57B1/6 mice that weighed 18-20 grams during the tests. These must have been mice of about 8 weeks old. The test animals were therefore very young. Lab mice can live about 2-3 years.

The researchers disabled one hind leg of the mice, so that they had to make do with the other leg. The muscles in that hind leg were therefore put under extra strain and became larger and stronger. During this experiment, half of the mice were orally administered a daily supplement with trigonelline.

If the mice had been adult humans, they would have been given about 1 to 1.5 grams of trigonelline per day. However, that is not necessarily the dose that people should use, according to DSM.

"While dosages may vary, they may range from at least 5 mg per day for a human," the researchers write. "More preferably from 10 to 3000 mg/day for a human and even more preferably from 50-500 mg/day for a human."

Results
At the end of the 3 weeks, the gastrocnemius muscle in the active hind paw was 7 percent heavier if the mice had received trigonelline than the gastrocnemius in the active paw of the animals that had not received the active substances.

In another experiment, the researchers placed the mice in a kind of wheelchair for 3 weeks, which prevented them from using their hind legs. Half of the mice received trigonelline, the other half did not.

When the experiment ended, the muscles in the disabled legs of the test animals were 9 percent heavier in the mice that had been given trigonelline.

The researchers also studied the effect of trigonelline on endurance performance of mice. Nothing came of that.

Conclusion
Interesting stuff, that trigonelline. Let's see if we can find out more about that...

Source:
US Patent 8,323,707 B2
European Patent 2 269 607 A1

More:
Trigonelline keeps you fit and strong as the years go by 24.03.2024
More vitamin B3 gives people over 40 more muscles and less body fat 19.02.2024
Nicotinamide-riboside extends life expectancy and rejuvenates muscles 09.09.2016
Nicotinamide-riboside transforms muscle cells into super muscle cells 27.07.2016

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