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12.09.2023


Citrus flavonoid hesperidin stops muscle breakdown due to aging

Hesperidin, a flavonoid found in significant amounts in oranges, inhibits muscle breakdown and stimulates muscle building. This is suggested by a Korean animal study conducted with older lab mice.


Citrus flavonoid hesperidin stops muscle breakdown due to aging


Study
Biotechnologists from CHA University in South Korea gave elderly 2-year-old lab mice hesperidin dissolved in drinking water every day for 8 weeks. The Koreans administered the flavonoid via the oral route. If the mice had been adult humans, they would have been given about 40 [the lowest dose] or 80 milligrams of hesperidin daily.

Another group of older mice received no active substances.

When the 8 weeks were over, the researchers studied the muscle tissue of the test animals. They compared the tissue with that of young mice.

Results
The old mice [OM] had less quadriceps [QUA] and gastrocnemius muscle mass [GAS] than the young mice [YM]. Supplementation with hesperidin [HES] reduced the difference.


Citrus flavonoid hesperidin stops muscle breakdown due to aging

Citrus flavonoid hesperidin stops muscle breakdown due to aging

Citrus flavonoid hesperidin stops muscle breakdown due to aging


Hesperidin reduced the activity of inflammatory proteins such as TNF-alpha and interleukin-1-beta and catabolic signaling molecules such as MURF1 in the old mice. This is indicated by the figures above.

At the same time, hesperidin supplementation increased the activity of anabolic signaling molecules, such as p-mTOR, p-AKT, myogenin and myo-D. The figures below refer to the quadriceps.


Citrus flavonoid hesperidin stops muscle breakdown due to aging

Citrus flavonoid hesperidin stops muscle breakdown due to aging


Conclusion
No side effects occurred during the 8 weeks of the experiment. Therefore, and because their experiments showed that hesperidin slows down muscle breakdown due to aging, the Koreans conclude that hesperidin "can be used as a functional food for delaying sarcopenia in the elderly".

Hesperidin is found in oranges, especially blood oranges. A 200 milliliter glass of fresh blood orange juice contains approximately 80 milligrams of hesperidin. [J Agric Food Chem. 2000 Nov;48(11):5501-6.] An equal glass of juice from regular oranges contains 50 milligrams. [J Agric Food Chem. 1994 Oct;42:(10)2183-90.] If people respond to hesperidin in the same way as mice, then you should get active amounts of hesperidin through oranges.

Source:
Cells. 2023 Aug 7;12(15):2015.

More:
Hesperetin, the cellular rejuvenator from citrus fruits 21.08.2022
Dutch research | Hesperidin improves sports performance 05.03.2021
Hesperidin stimulates formation of new muscle tissue 15.10.2012

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