Rutin, a natural medicine against type-2 diabetes
Rutin suplementation increases insulin sensitivity and improves cholesterol levels in people with type 2 diabetes. It even seems that supplementing with rutin may protect the brains of diabetics.
Hadi Bazyar, a diabetologist from Ahvaz Jundishapur University of Medical Sciences in Iran, divided 50 people with type 2 diabetes into 2 equally sized groups. Most subjects used medication, but no insulin yet.
For 3 months, the subjects in one group took a placebo daily after a meal. The subjects in the other group took a capsule containing 500 milligrams of rutin. Rutin is a metabolite of quercetin that has antioxidant and anti-inflammatory properties. Bayzar used a Solgar product.
Rutin supplementation reduced the subjects' diabetes symptoms. Early morning fasting glucose [FBG], insulin levels, and degree of insulin resistance [HOMA-IR] decreased by 21, 21, and 41 percent, respectively. In a way the researchers don't fully understand, rutin increases insulin sensitivity in this group.
Click on the tables below for a larger version.
The reduction in diabetes resulted in a healthier cholesterol balance, with 24, 11 and 9 less 'bad' LDL, VLDL and triglycerides respectively and 16 percent more 'good' HDL.
There was also a trend that rutin supplementation increased the concentration of BDNF in the blood by 6 percent. This may mean that rutin reduces the risk of dementia in diabetics.
"It seems that rutin flavonoid supplement may have beneficial effects on type-2 diabetes mellitus", writes Bayzar. "Nevertheless, more studies are needed to confirm the results."
Phytother Res. 2023 Jan;37(1):271-84.
This analogue of rutin extends life by 10 percent 31.01.2023
Rutin boosts endurance capacity 10.12.2015
Half a gram of rutin a day can fight fat 09.12.2015
Animal study shows that rutin supplement is anti-catabolic in bone tissue 08.03.2012
Insulin & Glucose Metabolism
Rutin & Quercetin