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30.08.2024

Heavy dose of biotin for more testosterone | Animal study

In almost any online store that sells supplements, you will undoubtedly find a heavily dosed supplement that provides 10 milligrams of biotin per tablet. According to the Japanese animal study that an attentive reader recently sent us, such a supplement could increase men's testosterone levels.

Study
Researchers from Tohoku University gave male mice a high dose of biotin. The researchers injected the biotin directly into the small intestine of the animals. If the mice had been adult men, they would have been given 10-14 milligrams of biotin.

Six hours after administration, the researchers studied the effect of the vitamin on the testes.

The researchers could also have simply administered the vitamin orally. The bioavailability of biotin when administered orally is 100 percent. So it couldn't be better. [Am J Clin Nutr. 1999 Mar;69(3):504-8.]

Results
In the blood of laboratory animals [serum] and in the tissue of the testes, the concentration of testosterone increased by a factor of 3 and 1.3, respectively, after administration of biotin.

The concentration of LH did not increase by administration. This means that biotin directly affects the biosynthesis of testosterone in the testes.

In the blood of laboratory animals [serum] and in the testes, the concentration of testosterone increased by a factor of 3 and 1.3, respectively, after administration of biotin.

The concentration of LH did not increase by administration. This means that biotin directly affects the biosynthesis of testosterone in the testes.

Active group
The researchers conducted in vitro studies in which they exposed testes cells not only to biotin, but also to valeric acid, lipoic acid and desthiobiotin. They wanted to find out which part of the biotin molecule is most important for the production of testosterone.

Desthiobiotin did not increase the cells' production of testosterone, valeric acid and lipoic acid. This means that the imidazole ring of biotin is important for the effect.

Conclusion
"These results suggest that biotin may have the potential to improve age-related male syndromes associated with declining testosterone production", write the researchers.

Source:
Nutrients. 2022 Nov 10;14(22):4761.

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