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01.08.2025

The antidiabetic effect of glucosamine

Glucosamine has a modest but clinically relevant protective effect against diabetes type-2. Supplementation not only reduces the chance that you will get diabetes, but also protects against cardiovascular complications if you already have diabetes.


Glucosamine has a modest but clinically relevant protective effect against diabetes type-2. Supplementation not only reduces the chance that you will get diabetes, but also protects against cardiovascular complications if you already have diabetes.


Study 1
In 2020, American-Chinese epidemiologists published an analysis based on data from over 400,000 study participants who had been followed for an average of 8 years as part of the UK Biobank study. The researchers had insight into the participants' lifestyle - and also knew whether the participants were taking glucosamine supplements.

Supplementation with glucosamine reduced the risk of developing type 2 diabetes by 17 percent, the researchers found, after statistically accounting for all other influencing factors.

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Glucosamine has a modest but clinically relevant protective effect against diabetes type-2. Supplementation not only reduces the chance that you will get diabetes, but also protects against cardiovascular complications if you already have diabetes.


The researchers also knew whether the study participants carried genetic variants that increased the risk of diabetes. In all groups, glucosamine offered protection against type 2 diabetes.


Glucosamine has a modest but clinically relevant protective effect against diabetes type-2. Supplementation not only reduces the chance that you will get diabetes, but also protects against cardiovascular complications if you already have diabetes.


Study 2
In 2025, epidemiologists from Suzhou Medical College of Soochow University in China published another analysis based on data from the UK Biobank study. [Nutr Diabetes. 2025 Apr 1;15(1):12.] The researchers followed more than 12,000 people with type 2 diabetes for a period of 12 years.

When the study began, diabetes had not yet damaged the participants' blood vessels. The researchers found that glucosamine supplementation reduced the risk of microvascular complications by 11 percent.


Glucosamine has a modest but clinically relevant protective effect against diabetes type-2. Supplementation not only reduces the chance that you will get diabetes, but also protects against cardiovascular complications if you already have diabetes.


For the study participants in the Biobank study, the exact amount of glucosamine they used is unknown. The duration of use and the type of supplement were also not recorded.

Source:
Diabetes Care. 2020 Apr;43(4):719-25.

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Archives:
Insulin & Glucose Metabolism
Glucosamine


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