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25.12.2022

A capsule of shilajit a day makes bones stronger

Supplementation with shilajit, an oily preparation originating from the Asian high mountains, is not only interesting for men who want to increase their testosterone levels. According to a small trial published in Phytomedicine, shilajit also has an anabolic effect in bone tissue.

Study
Usharani Pingali and Chandrasekhar Nutalapati, two researchers from Nizam's Institute of Medical Sciences in India, divided 60 women aged 45-65 into 3 groups. All women were postmenopausal. In this group, bone mass usually decreases gradually.

The women in the control group took a placebo every day for 48 years.

Women in the 2 experimental groups took 250 or 500 milligrams of shilajit daily. The researchers used PrimaVie, a Natreon product. [natreoninc.com]

Natreon sponsored the trial. The company supplied Pingali and Nutalapati with the supplements and equipment to analyze their test subjects' blood.

Results
Shilajit supplementation increased bone mass.

Mechanism
Supplementation with shilajit led to a decrease in receptor activator of nuclear factor kappa-B ligand in the subjects' blood. This molecule - spatial structure below - activates NFkB, an important molecular switch that activates inflammatory and degradative processes.

In bone tissue, NFkB activates the osteoclasts. Osteoclasts are bone cells that break down bone tissue.

At the same time, shilajit increased the concentration of osteoprotegerin. Osteoprotegerin is a protein that prevents receptor activator of nuclear factor kappa-B ligand from interacting with NFkB.

Finally, supplementation with shilajit led to a decrease in MDA, a marker of free radical damage, and an increase in the endogenous antioxidant GSH. The concentration of NO increased sharply due to supplementation.

Click on the figure below for a larger version.

Conclusion
"Diet is a modifiable factor acknowledged to influence bone health (e.g., adequate protein, calcium, magnesium, and vitamin D, increased consumption of fruits and vegetables, limiting alcohol intake), but implementing and sustaining major dietary changes can be challenging", write Pingali and Nutalapati.

"Dietary supplementation is a useful tool to incorporate potentially beneficial dietary components that are not sufficiently consumed in the habitual diet."

"This research highlights an easily implemented dietary modification in the form of a supplemental dietary ingredient with established safety to attenuate elevations in inflammation, oxidative stress, and bone loss in postmenopausal women."

Source:
Phytomedicine. 2022 Oct;105:154334.

More:
Only strong athletes get stronger through shilajit supplementation 19.11.2022
Shilajit boosts concentration of testosterone, free testosterone and DHEA 26.01.2016
Shilajit boosts fertility and testosterone level 04.10.2012

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