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28.06.2023


What happens if you use alpha-lipoic acid for 4 years?

Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.


Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.


Study
Giuseppe Derosa, an Italian diabetologist from the University of Pavia, gave 322 subjects a daily supplement with alpha-lipoic acid for 4 years. There were no control groups.

Some of the subjects had normal glucose levels [eugleucemic, EU], some had high glucose levels on an empty stomach (impaired fasting glycemia, ITG] and some did not respond well to glucose (impaired glucose tolerance, IGT).

The test subjects did not use any medication, but some of them were in the process of becoming diabetic.

Derosa used a regular product. The capsules therefore contained a racemic mixture containing the R- and S- variants of alpha-lipoic acid. Derosa says nothing about the producer of the supplements used. His research was not sponsored by any manufacturer.


Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.


Results
Supplementation with a high dose of alpha-lipoic acid improved glucose metabolism and reduced the concentration of triglycerides in the blood. In the 1200 milligram group, the fasting glucose level dropped by 12 percent, the concentration of triglycerides by 21 percent.

The researchers found no statistically significant changes in the subjects who had taken 400 or 600 milligrams of alpha-lipoic acid daily. They did find it in the test subjects who had taken 800 or 1200 milligrams daily.

The first table below refers to the subjects' values before supplementation started, the second after 4 years of supplementation.

Click on the tables for a larger version.


Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.

Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.

Supplementation with alpha-lipoic acid improves the sensitivity of insulin in people who do not yet need antidiabetic medication, but may already be developing diabetes. However, the dose of alpha-lipoic acid required for this is somewhat on the high side.


In the groups that took 800 or 1200 milligrams of alpha-lipoic acid daily, a limited number of subjects with an elevated fasting glucose level or reduced insulin sensitivity became euglycemic.

Side effects
A few subjects experienced adverse reactions such as nausea, vomiting, dizziness, rash, hypoglycaemia and hypotension. However, high-dose users were no more likely to be affected than low-dose users.

Source:
Drug Des Devel Ther. 2020 Dec 3;14:5367-74.

More:
Alpha-Lipoic Acid fights carpal tunnel syndrome symptoms 02.06.2018
Alpha-Lipoic Acid combined with training boosts EPO levels 21.12.2015
Alpha-Lipoic Acid boosts effect of creatine 07.02.2014

Archives:
Insulin & Glucose Metabolism
Cardiovascular Health
Alpha Lipoic Acid


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