Supplement with glycine and N-acetylcysteine lowers insulin resistance in type-2 diabetics
Supplementation with GlyNAC, a combination of glycine and N-acetyl cysteine, allows mice to live much longer, we wrote a few months ago. The same supplement makes type 2 diabetics a lot healthier. But oh my gosh, what gigantic doses did American researchers need for that...
Rajagopal Sekhar, a diabetologist from Baylor College of Medicine in the US, invests a lot of his time and energy in GlyNAC. He publishes extensively on the supplement and holds a number of patents for the medical use of GlyNAC. [patents.justia.com]
In the first months of 2022, Sekhar published a small study in which 10 people with type 2 diabetes used GlyNAC every day for 14 days. GlyNAC consists of equal parts glycine and NAC. The subjects received 1 gram of glycine and 1 gram of NAC per 10 kilograms of body weight daily.
This dose is quite high. Don't try this at home, folks.
All subjects were treated by a physician. They were given medication, but did not yet use insulin.
Just before and in the final phase of the supplementation period, Sekhar analyzed the subjects' breath. This happened early in the morning, even before the subjects had had breakfast.
Sekhar found that supplementing with GlyNAC increased carbohydrate oxidation by 30 percent.
Diabetes implies that cells cannot properly take up glucose, but GlyNAC improved that ability to some extent. This is also apparent from the effect on the insulin resistance of the test subjects in the GlyNAC group. It decreased by 22 percent.
"These results could have important implications for improving health in diabetes, and support the need for a randomized clinical trial to confirm these findings and to understand the impact of GlyNAC supplementation on defects linked to mitochondrial dysfunction in diabetes", writes Sekhar.
Antioxidants (Basel). 2022 Jan 13;11(1):154.
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Insulin & Glucose Metabolism