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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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09.03.2022 |
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Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent
GlyNAC is a mixture of equal parts glycine and N-acetylcysteine [NAC]. An animal study recently published in Nutrients suggests that human beings may live forty percent longer if they ingest a few grams of GlyNAC every day.
Study
Some of the mice were fed standard chow for the rest of their lives. This was the control group.
The other part of the mice was given food to which the researchers had added a mixture of equal parts glycine and N-acetylcysteine [NAC]. If the mice had been adult humans, they would have consumed approximately 2-3 grams of the amino acid combination daily.
The researchers call their combination GlyNAC. They have recently published several studies on it. GlyNAC is already on the market.
Results
You can see above how GlyNAC probably extended the lifespan. To start with, supplementation increased the concentration of glutathione [tGSH] and reduced glutathione [rGSH] in the older laboratory animals [OG]. Thanks to the supplement, this concentration returned to the level expected in young mice [Y].
OC = old lab mice in the control group.
Glutathione is a molecule that detoxifying enzymes need to function properly. An important claim of the researchers is that GlyNAC works by increasing the concentration of glutathione in the cells.
Probably due to the increase in the concentration of glutathione, the concentration of TBARS in the cells of the mice decreased. That means that oxidative stress decreased.
GlyNAC also increased the activity of PGC-1-alpha, a genetic molecular switch that forces cells to make more mitochondria. Mitochondria convert nutrients into energy.
At the same time, GlyNAC increases the activity of the enzyme PINK1. PINK1 clears out senescent mitochondria.
Senescent mitochondria are like leaking nuclear power plants that have had their day. They poison the cells, and they don't produce much energy anymore. During the aging process, the number of defective mitochondria in the cells increases. GlyNAC apparently puts a stop to that.
Patents
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