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09.03.2022


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent

GlyNAC is a mixture of equal parts glycine and N-acetylcysteine [NAC]. An animal study recently published in Nutrients suggests that human beings may live forty percent longer if they ingest a few grams of GlyNAC every day.


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent


Study
Researchers from Baylor College of Medicine in the US experimented with mice aged 65 weeks. If the mice had been humans, they would have been in their forties.

Some of the mice were fed standard chow for the rest of their lives. This was the control group.

The other part of the mice was given food to which the researchers had added a mixture of equal parts glycine and N-acetylcysteine [NAC]. If the mice had been adult humans, they would have consumed approximately 2-3 grams of the amino acid combination daily.

The researchers call their combination GlyNAC. They have recently published several studies on it. GlyNAC is already on the market.

Results
The mice in the GlyNAC group lived longer than the mice in the control group. After 121 weeks, all mice in the control group had died. In the GlyNAC group, this happened after 169 weeks. This means that GlyNAC extended the maximum life span by as much as 40 percent.


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent


You can see above how GlyNAC probably extended the lifespan. To start with, supplementation increased the concentration of glutathione [tGSH] and reduced glutathione [rGSH] in the older laboratory animals [OG]. Thanks to the supplement, this concentration returned to the level expected in young mice [Y].

OC = old lab mice in the control group.

Glutathione is a molecule that detoxifying enzymes need to function properly. An important claim of the researchers is that GlyNAC works by increasing the concentration of glutathione in the cells.

Probably due to the increase in the concentration of glutathione, the concentration of TBARS in the cells of the mice decreased. That means that oxidative stress decreased.


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent


Animal study | Combination of glycine and NAC extends maximum lifespan by 40 percent


GlyNAC also increased the activity of PGC-1-alpha, a genetic molecular switch that forces cells to make more mitochondria. Mitochondria convert nutrients into energy.

At the same time, GlyNAC increases the activity of the enzyme PINK1. PINK1 clears out senescent mitochondria.

Senescent mitochondria are like leaking nuclear power plants that have had their day. They poison the cells, and they don't produce much energy anymore. During the aging process, the number of defective mitochondria in the cells increases. GlyNAC apparently puts a stop to that.

Patents
Rajagopal Sekhar, the research leader of the team that did the study we're boring you with today, has a number of patents to his name covering the use of GlyNAC as a glutathione booster in a medical-therapeutic context. [US20210244696A1.] [US9084760B2.] [WO2021232041A1.]

Source:
Nutrients. 2022, 14, 1114.

More:
Glycine supplementation extends life span 22.06.2019
Glycine AKG a longevity supplement? 25.08.2015
Glycine rejuvenates old cells 24.08.2015

Archives:
Amino Acids
Longevity
Glycine
NAC


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