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19.06.2022


Dietary spermidine extends your lifespan (by maybe 6 years)

Many, many foods contain spermidine. It is a polyamine to which nutritional science has never paid much attention. Wrongly, according to recent research. If you have a lot of spermidine in your diet, your lifespan may increase by several years.


Dietary spermidine extends your lifespan (by maybe 6 years)


Spermidine
If you give spermidine to mice, the aging of their heart muscle slows down. [Another mouse study] Spermidine increases the number of mitochondria.

However, the human equivalent of the dose required for this is very high. You are quickly talking about several hundred milligrams per day.

It is mainly a group of Austrian scientists, affiliated with the University of Applied Sciences Wiener Neustadt, who are studying the longevity effects of spermidine. They published, among other things, a small epidemiological study in which a relatively high level of spermidine in people over sixty correlated with a better memory function.

In 2018, the Austrians published a small trial in which supplementation with slightly more than one milligram of spermidine per day seemed to improve the memory of people over 60.


Dietary spermidine extends your lifespan (by maybe 6 years)


Study
In 2018, Austrian researchers at the Medical University of Innsbruck published an epidemiological study in which they followed a group of 829 study participants aged 45-84 for twenty years.

The researchers knew the diet and lifestyle of the study participants and looked for the link between the intake of spermidine through food and longevity.

Results
The main sources of spermidine in the group studied were whole grains, apples, pears and salads.


Dietary spermidine extends your lifespan (by maybe 6 years)


Based on their spermidine intake, the Austrians divided their study participants into 3 equally sized groups.

Study participants who consumed less than 9.2 milligrams of spermidine per day formed the low intake group, study participants who consumed 9.2 to 11.6 milligrams daily formed the middle intake group, and study participants who consumed more than 11.6 milligrams of spermidine per day formed the high intake group.

The risk of death was greatest in the low intake group, and lowest in the high intake group. On the right in the figure below, the difference was good for 5.7 years.


Dietary spermidine extends your lifespan (by maybe 6 years)



Dietary spermidine extends your lifespan (by maybe 6 years)



The researchers filtered out various other factors several times. But no matter how thoroughly the researchers did this, the life-prolonging effect remained.

Click on the table above for a larger version.

Conclusion
"In summary, this study provides the first evidence, to our knowledge, for an association between nutrition rich in spermidine and increased survival in humans", summarize the Austrians.

"If confirmed in future intervention trials, our study may have implications for health education at a population level advocating high spermidine content as a novel feature of a healthy diet."

Source:
Am J Clin Nutr 2018;108:371-80.

More:
Spermidine keeps the heart young | Animal study 15.06.2022
Spermidine improves memory in over-60s | Pilot study 10.09.2020
Do spermidine supplements prevent dementia? 08.09.2020

Archives:
Spermidine
Longevity


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