Spermidine supplementation stops cardiovascular aging
If you are up to date with developments in the longevity scene, then you know spermidine. Not everyone is fond of the spermidine supplements currently available in online stores, but that spermidine is an interesting substance, that is clear. We read the animal study that Chinese researchers at Harbin Medical University published in Aging, and we must confess that our interest has now also been aroused.
Spermidine is a polyamine. Living organisms produce the substance through the metabolism of arginine, among other things, but spermidine is also found in foods. Wheat germ is the best source. A tablespoon of wheat germ - wheat germ in English - of 7 grams contains about 1.7 milligrams of spermidine. That is as much as most spermidine supplements provide per daily dose.
We found the table below on Wikipedia.
The biological functions of spermidine are not yet known, but in vitro and animal studies suggest that spermidine has an anti-aging effect. The researchers at Harbin Medical University tried to gain more insight into this longevity aspect with their animal study.
The researchers gave old lab rats spermidine daily for 6 weeks. They injected the substance directly into the small intestine of their lab animals.
If the animals had been adult humans, and had taken the spermidine orally, they would have consumed roughly 200-300 milligrams of spermidine per day.
When the 6 weeks were up, the researchers compared the heart cells of their rats [SPD] with the heart cells of young rats, and the heart cells of another group of old rats. Those two control groups had not been treated with spermidine.
Aging reduced the amount of mitochondria in the heart cells. So the cells could generate less energy. However, supplementation with spermidine canceled this aging effect.
Spermidine increased the concentration of the anti-aging enzyme SIRT1 in the heart cells and activated signaling molecules such as PGC-1-alpha and TFAM. They are involved in the production of mitochondria.
"These findings might guide new therapeutic strategies for counteracting cardiac aging and preventing age-related cardiovascular diseases, and lay a foundation for improving the treatment of heart diseases related to mitochondrial dysfunction", write the researchers.
More coming soon.
Aging (Albany NY). 2020 Jan 6;12(1):650-71.
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