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04.08.2021

Bioavailability of quercetin phytosome is 20 times greater than that of regular quercetin

Virologists fear that the coronavirus will make a comeback this fall, so interest in supplements that may protect against the pesky bioentity is growing. Quercetin is such a supplement. Unfortunately, the bioavailability of quercetin is low. An Italian producer of ingredients for the supplement industry has solved that problem.

Phytosome
The supplements we are referring to contain a form of quercetin developed by the Italian company Indena. Indena packs bioactive substances into phytosomes: structures of small spheres consisting of lecithin. Each sphere contains quercetin.

Similar structures also arise in the digestive organs, especially if fats are also present. They are crucial for the absorption of a broad spectrum of active substances.

By prepackaging quercetin in this way, Indena hopes to increase the absorption of natural active substances. Indena has applied the same technology to curcumin and green tea extract.

Study
In 2019, Indena published a self-funded study in which 12 subjects took a supplement containing quercetin on three different occasions.

One time the supplement was a capsule with 500 milligrams of regular quercetin, another time a capsule with 250 milligrams of quercetin phytosome and another time a capsule with 500 milligrams of quercetin phytosome.

Results
The figure below speaks for itself. The enhanced bioavailability of quercetin in a phytosome complex is undeniable.

A good way to determine the bioavailability is the area under the curve [AUC]. You can deduce from the table below that the bioavailability of quercetin phytosome is a factor of 20 greater than that of regular quercetin.

The table above is simplified. Click it for a full version.

Source:
Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):169-77.

More:
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Quercetin

Quercetin sabotages influenza virus In test tubes, quercetin, a flavonoid found in many plant foods, makes it difficult for influenza A viruses to infect cells.	This supplement reduces the risk of coronavirus infection by a factor of 12 The ingredients - vitamin C, quercetin, and bromelain - can be found in every webshop or vitamin shop.	Quercetin protects athletes from colds and flu Quercetin has an antiviral effect in vitro, we wrote yesterday. Quercetin may also reduce the risk of virus infections in real people, especially if they train intensively.