Supplementation with green tea extract Greenselect Phytosome: more growth hormone and accelerated fat loss
If we had not encountered studies in which tea extracts increase the release of growth hormone, we would have postponed this Italian research as completely implausible and then completely ignored. But the fact that we write about it does not mean that we really believe that a few hundred milligrams of Greenselect Phytosome significantly increases the concentration of growth hormone and IGF-1 in your body, lowers the cortisol level and makes pounds of excess fat disappear like snow in the sun. Caveat emptor.
The authors of the study with which we are now bothering you, are affiliated with Italian Velleja Research. [vellejaresearch.com] The authors developed the extract that they tested in this study. Another Italian company, Indena, [indena.com] markets it as Greenselect Phytosome. [greenselect.phytosome.info] So we consider this research as sponsored.
The researchers put a group of 100 obese people aged 25-60 years without diabetes on a weight-loss diet for 90 days. Half of them took a capsule with 150 milligrams of Greenselect Phytosome twice a day.
The subjects who only kept diet [A] lost 5 kilos, the subjects who also took Greenselect Phytosome [B] weighed 14 kilos.
In 20 subjects, the researchers analyzed the blood. Supplementation increased the concentration of growth hormone by a factor of 3 and also improved cholesterol. By the way, both effects are just as hard to believe as the effect on weight loss.
The extract finally lowered the concentration of cortisol and increased the concentration of IGF-1.
"Considering the high safety profile of the active ingredient (Greenselect Phytosome) used in the formulation and the absence of relevant side effects in treated subjects compared to untreated subjects, the product can be considered a safe and effective tool for weight loss and impacting obesity-related risk factors", write the researchers.
"Additional studies are needed to determine whether the product demonstrates an anti-obesity effect without the hypocaloric diet. Moreover, the mechanism of action of the formulation's effect on lipid profiles, leptin, and other biochemical markers linked to obesity needs to be investigated."
If researchers will do further research into Greenselect Phytosome, we have a suggestion for them: is this application really safe? Because some people experience liver abnormalities due to green tea catechins, EFSA believes that we should not consume more than 800 milligrams of EGCG daily. [EFSA Journal 2018;16(4):5239.]
However, this guideline is based on research into unmodified products, not on sophisticated products such as Greenselect Phytosome. The manufacturers of Greenselect Phytosome have the catechins from green tea [the most important of these is EGCG] wrapped in phospholipids. As a result, the bioavailability of these catechins increases considerably, the researchers reported in 1998. [Biochem Mol Biol Int. 1998 Dec;46(5):895-903.]
This raises questions about the safety of Greenselect Phytosome. At which intake of this extract do sensitive individuals get abnormal liver values?
Altern Med Rev. 2009 Jun;14(2):154-60.
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Weight Loss Supplements
Growth Hormone & IGF-1