Black pepper extract PipeNig-FL stimulates muscle growth while inhibiting body fat growth
A new extract of black pepper - Piper nigrum in Latin - may help athletes to build more muscle mass and at the same time block the growth of their fat mass. According to an in vitro study that Italian biologists from the University of Turin published in Nutrients, the active substances in the extract are active in a concentration of 1 nanomol.
PipeNig-FL is an extract of black pepper and a product of the Italian ingredient manufacturer Biosfered. [biosfered.com] Biosfered paid part of the costs of the research that this posting is about. Moreover, one of the co-authors of the publication was a Biosfered employee.
When sports supplement users encounter black pepper extracts, they usually contain bioperine. Because bioperine in the small intestine eliminates some enzymes, the uptake of a wide range of bioactive substances increases. However, PipeNig-FL is a completely different kind of extract. It mainly contains trans-beta-caryophyllene [structural formula at the top of the page].
Below you can see the composition of PipeNig-FL.
Biosfered has had human research carried out into the analgesic effect of PipeNig-NL, but suspects that the new extract has even more interesting biological effects. Hence the in vitro research by the University of Turin.
When the researchers exposed muscle cells in test tubes to a labeled form of glucose and PipeNig-FL, they saw that the extract increased glucose uptake by muscle cells. In muscle cells trans-beta-caryophyllene activated the glucose transporter GLUT4 [bottom right]. That happened in a concentration of 1 nanomol [bottom left] - which is surprisingly low.
In fat cells, trans-beta-caryophyllene blocked the increase in the amount of stored fat [top right]. Fat cells biosynthesize that fat primarily by converting glucose. Apparently, trans-beta-caryophyllene inhibits the uptake of glucose from fat cells. However, the active substance in PipeNig-FL was not harmful to the fat cells.
"GLUT4 levels are significantly reduced in the skeletal muscle or type 2 diabetic patients and in insulin resistant patients", the researchers write. "The development of therapeutic compounds able to induce GLUT4 expression/translocation can thus improve insulin sensitivity and reduce insulin resistance."
"Several plant-derived bioactive molecules have been listed as stimulators of GLUT4 translocation and/or expression, among these resveratrol, chlorogenic acid, daidzein, curcumin and astaxanthin. As a major component of PipeNig-FL, trans-beta-caryophyllene, could now be included in this list."
Nutrients 2019, 11, 2788; doi:10.3390/nu11112788.
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