Pantethine | The underrated cholesterol-lowering effects of a B vitamin
Pantethine, a form of vitamin B5, can improve cholesterol levels in a way you wouldn't expect from a substance available as a supplement. According to a somewhat older meta-study, the positive effects increase over time.
In 2005, the American physiologist and biochemist Marc McRae published a meta-study in which he brought together and reanalyzed the results of 28 previously published trials. In the trials, researchers studied the effect of pantethine supplementation on the concentration of LDL, HDL and triglycerides in the blood.
Pantethine is a form of vitamin B5. You can read more about the cardiovascular effects of pantethine here.
The oldest trial used by McRae dates back to 1966.
Most trials were small and were conducted on a few dozen participants. On average, the test subjects received about 900 milligrams of pantethine per day for several months.
Based on the 28 trials, McRae made the figure below.
It shows that for 4 months the effect of pantethine increases. After 4 months, LDL and triglyceride levels have generally decreased by 20 and 33 percent, respectively. At the same time, after 4 months, the average HDL level increased by 8 percent as a result of supplementation.
"Over the long term, there does not appear to be any severe adverse reactions associated with pantethine administration, even in patients who have been receiving treatment for more than 1 year", writes McRae.
"However, very mild adverse reactions have been reported, such as heartburn, mild pruritis, and diarrhea. Although the percentage of subjects experiencing adverse effects was 3.6%, two thirds of these were observed in one single study."
"Pantethine supplementation has the potential to address the serious problem of protecting the arterial walls from the atherogenic effects of a disordered blood lipid profile."
Nutrition Research 2005; 25(4):319-33.
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