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24.01.2024


Metastudy confirms quercetin's antiviral potential against Covid-19

In case of Covid-19, a daily dose of at least 600 milligrams of quercetin may reduce the risk of admission to hospital, the need for ICU treatment and death. This is suggested by a meta-analysis published in Food Science & Nutrition.


Metastudy confirms quercetin's antiviral potential against Covid-19


Study
Researchers from Kermanshah University of Medical Sciences in Iran traced 5 previously published trials in which a total of 544 subjects with a not too serious form of Covid-19 served as test subjects.

All trials were double-blind and randomized. The subjects in the groups receiving quercetin were given the flavonoid in doses of 500-1500 milligrams per day for 1-4 weeks.

The trials date from 2021-2023. The methodology of the trials was not perfect. There was something to note about the design of each trial, as shown in the table below. Click on it for a larger version.


Metastudy confirms quercetin's antiviral potential against Covid-19


Metastudy confirms quercetin's antiviral potential against Covid-19


Results
Supplementation with 600-1000 milligrams per day of quercetin reduced the chance that the subjects had to be admitted to hospital by 70 percent, the chance of a stay in the ICU by 73 percent and the chance of death by 82 percent.


Metastudy confirms quercetin's antiviral potential against Covid-19


In the trials, quercetin inhibited the increase in the enzyme LDH in the blood of the test subjects. This suggests that the virus caused less damage at the cellular level.

As with MERS and SARS, the virus can cause a severe immune reaction that causes more damage, especially in the lungs, than the body can handle. In addition, the immune reaction activates the formation of blood clots. The researchers suspect that quercetin dampens these immune responses.

Mechanism
Quercetin probably frustrates the entry of the SARS-CoV-2 virus into cells via the ACE-2 receptor. At the same time, quercetin inhibits viral enzymes such as 3CLPro and RNA-dependent RNA polymerase (RdRp). Because the virus needs these enzymes to replicate in cells, quercetin gives the immune system more opportunity to deal with the virus.

Conclusion
"The findings from this systematic review and meta-analysis demonstrate its potential as a therapeutic agent against Covid-19", summarize the Iranians. "Due to the low certainty of evidence, these results should be interpreted with caution."

Source:
Food Sci Nutr. 2023 Sep 26;11(12):7504-14.

More:
High-dose quercetin protects against colds - if you're 40+ and fit 29.01.2022
Does quercetin take the sting out of covid? 12.08.2021
Covid patients recover faster with quercetin phytosome supplementation 09.08.2021
Animal study | Quercetin helps prevent virus infection after strenuous exercise 16.12.2020
Quercetin protects athletes from colds and flu 08.04.2020
Quercetin sabotages influenza virus 07.04.2020

Archives:
Immune System
Quercetin


How vitamin C boosts quercetin's antiviral action This supplement reduces the risk of coronavirus infection by a factor of 12 Quercetin makes zinc a better corona protector

How vitamin C boosts quercetin's antiviral action
The antiviral effects of zinc, vitamin C and quercetin reinforce each other, say supplement experts. The more we delve into the matter, the more convinced we become that they are right.

This supplement reduces the risk of coronavirus infection by a factor of 12
This supplement provided the test subjects with 500 milligrams of quercetin, 500 milligrams of vitamin C and 50 milligrams of bromelain daily.

Quercetin makes zinc a better corona protector
Zinc supplementation can reduce the risk of corona infection and complications, we reported a few weeks ago. The protective effect of zinc is probably even stronger when co-supplemented with quercetin.