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22.11.2023

Increase in liver enzyme values? Maybe curcumin will help

If your liver is having a hard time - and there is more AST and ALT in your blood than you would like - curcumin supplementation may help you get the situation under control. This is suggested by a meta-study published in Complementary Therapies in Medicine.

Study
Mohammad Jafar Dehzad, affiliated with Shiraz University of Medical Sciences in Iran, collected 31 previously published trials in which subjects were given supplements with turmeric or curcumin and researchers then measured the effect on liver enzymes such as ALT, AST and GGT in the blood. The higher these values ​​are, the harder the liver has to endure.

Dehzad combined the trials' results and reanalyzed them.

Results
Supplementation with curcumin or turmeric reduced the concentration of the liver enzymes ALT and AST by 4.1 and 3.9 points, respectively. The figures below tell us this. When you click on it, larger versions will pop up.

There was a trend for supplementation to decrease the concentration of GGT, but this decrease was not statistically significant.

When the Iranians broke down their data, they could not find a clear relationship between doses, duration of use and type of preparation on the one hand and the effects on the liver on the other. If you want to draw a cautious conclusion from that part of the publication, it boils down to the fact that curcumin preparations with increased bioavailability may be the best choice.

Conclusion
Because the quality of the studies used was not optimal, the researchers are cautious in the final sentences of their publication.

The present systematic review and meta-analysis shows that turmeric/curcumin supplementation significantly improves blood levels of ALT and AST, but not GGT", the reserachers summarize. "However, clinical effectiveness remains unassured."

"Further research is needed to discover the impact of such an intervention in various clinical conditions using more specific assessments of the hepatic health."

Source:
Complement Ther Med. 2023 Jun:74:102952.

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