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11.11.2011


Grape Seed Extract protects against prostate cancer

Men who take high doses of Grape Seed Extract over a longer period may be less likely to develop prostate cancer than men who don't take this supplement. Researchers at the University of Washington suspect this after studying 35,000 men aged between 50 and 76 over a period of six years.


Grape Seed Extract protects against prostate cancer


Study
The study, the results of which were published in Nutrition and Cancer, is part of the Vital project, an epidemiological research project to study the positive effects of long-term supplement use. This particular part of the project focused on prostate cancer.

The researchers looked at the use of supplements that would be expected to reduce the chance of prostate cancer, such as Grape Seed Extract, chondroitin, Q10, fish oil, garlic, Ginkgo biloba, ginseng, glucosamine and of course saw palmetto.

Of the 35239 study participants, 1602 men developed prostate cancer.

Results
Of all the supplements, Grape Seed Extract was the only one that reduced the likelihood of prostate cancer by a significant amount. Users had 41 percent less chance of developing prostate cancer than non-users.

Numbers 2 and 3 in the Anti-Prostate Cancer Top Ten are fish oil and ginseng, but neither performed well in this study.


Grape Seed Extract protects against prostate cancer


Grape Seed Extract protects against prostate cancer
When the researchers looked at whether long-term use of Grape Seed Extract significantly reduced the risk of prostate cancer using statistics, they found a p for trend of 0.17. That is, um, not enough reason to call the Minister of Health out of bed.

Mechanism
Grape Seed Extract contains phenols: flavones, phenolic acids and resveratrol. In experiments with prostate cancer cells, Grape Seed Extract and its components inhibit the transcription factor nuclear factor kappa-B, the inflammatory protein interleukine-6 and the biosynthesis of inflammatory factors produced by cyclooxygenase enzymes, thereby blocking the growth of prostate cancer cells.

Conclusion
This is the first study directed specifically at supplements' ability to protect against prostate cancer. Because not much is known, the researchers are cautious. "Any public health recommendation for grapeseed would require replication of our findings in humans as well as further clarification of mechanisms of action."

Source:
Nutr Cancer. 2011 May;63(4):573-82.

More:
Grape Seed Extract inhibits 'genetically inevitable' prostate cancer 14.07.2012
Gallic acid is the anti-cancer agent in Grape Seed Extract 12.11.2011

Archives:
Preventing & Surviving Cancer
Grape Seed Extract
Prostate Cancer


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Meta-study determines the protective effect of lycopene against prostate cancer
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