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14.05.2025

At this dose, arginine has a prosexual effect in men | Trial

Supplementation with 2 grams of arginine per day has a positive effect on the sexuality of depressed women, we wrote last week. According to an Italian trial, published in the Journal of Endocrinological Investigation in 2022, arginine also has a prosexual effect in men. Although the dose the Italians needed for this is a bit higher than 2 grams.

Study
Endocrinologists from Federico II University experimented with 98 men with erectile dysfunction due to impaired blood vessel function. The Italians divided the men into 2 groups, a placebo group and an experimental group.

The men in the experimental group took a dose of 2 grams of arginine 3 times a day with a meal for 3 months. In total, the men used 6 grams of arginine per day.

Results
The Italians had the men fill out the IIEF-6 questionnaire and gave the men a score based on their answers. The higher the score, the less trouble the men had with erectile dysfunction.

The scores in the experimental group did not change. In the arginine group, they rose from 20 to 24. This means that their moderate disorder changed into a mild disorder. [Table]

The researchers measured the blood flow to the men's penis before and during the experiment [PVS]. You can see that above. In the men who received a placebo, it did not change, but in the men in the other group it did.

In some of the men in the experimental group who initially had a moderate disorder, the blood flow even normalized completely. In the men with a more serious disorder, arginine had no impact on the blood flow.

In the experimental group, the HDL level rose from 57.9 to 60.8 milligrams per deciliter. So it rose by 2.9 points. That effect is small, but positive.

In the placebo group, the HDL dropped by 3.1 points from 58.6 to 55.5 mg/dl milligrams per deciliter. That is a drop of 3.1 points.

Conclusion
"Arginine might be an alternative treatment in mild - moderate vasculogenic erection disorder patients experiencing adverse effects or with contraindications for chronic treatment with PDE5-inhibiting compounds", the researchers conclude.

"Additional studies would be suited to further corroborate the encouraging results presented by the current study, and to further widen the field of arginine supplementation's clinical applicability."

Source:
J Endocrinol Invest. 2022 May;45(5):941-61.

More:
Two grams of L-arginine per day improves women's sexual functioning 06.05.2025
Supplement with Pycnogenol and L-arginine improves sexual functioning in men 06.12.2023
Piceatannol makes L-arginine a more effective nitrogen monoxide donor 12.09.2013
Mix of propionyl-L-carnitine and L-arginine improves erection 15.12.2011
Study: erection supplement with L-arginine and pycnogenol works (slightly) 02.09.2011

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