Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
41 percent more endurance after a short monster cycle of ergothioneine
Chastened by an unbroken series of disappointing results from human research, our love for animal studies has diminished considerably. But sometimes we come across an animal experiment on the web that makes us forget all the frustration and disappointment. Such as the wonderful study on the ergogenic effect of ergothioneine, which Theo Fovet published in Frontiers in Physiology.
Ergothioneine is an amino acid in mushrooms that, according to dozens of studies, has a broad protective effect. If the mice in the experimental group had been adult humans, they would have received about 50 milligrams of ergothioneine daily.
The mice that had been given ergothioneine were able of running 72 minutes. However, the mice in the control group had to give up after 50 minutes [bottom right figure]. This means that supplementation with ergothioneine increased endurance by as much as 41 percent.
This also explains why Fovet found equal activity of catabolic mechanisms in the muscles of both groups of test animals after the session.
Because ergothioneine has a protective effect, Fovet feared that, like megadoses of antioxidant vitamins, ergothioneine could subtly inhibit muscle growth. That was not the case. Anabolic markers such as the activity of 4EBP1 and RPS6, or the production of Akt, IGF-1 and mTOR were not lower in the muscles of the mice in the ergothioneine group after the session than in the control group.
Supplementation also had no adverse effect on markers of stem cell recruitment and the production and repair of mitochondria.