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04.01.2021


Schisandrin-B, the fat cell destroyer in Schisandra chinensis

Schisandrin-B, the fat cell destroyer in Schisandra chinensis
No, from the publication of Hiu Yee Kwan that appeared in Scientific Reports in 2017, you cannot infer that supplementation with Schisandra chinensis will help fitness and physique athletes to get rid off their subcutaneous fat reserves. But Kwan's study will undoubtedly inspire supplement developers. What would happen if you combined schisandrin-B, an active substance in schisandra, with caffeine?


Schisandrin-B, the fat cell destroyer in Schisandra chinensis



In vitro study
Kwan exposed 3T3-L1 fat cells to different concentrations of schisandrin-B, and found that at the highest concentrations of schisandrin-B, the vitality of the fat cells decreased. At lower concentrations, which didn't seem to harm the fat cells, schisandrin-B reduced the amount of fat stored in the cells.


Schisandrin-B, the fat cell destroyer in Schisandra chinensis
Schisandrin-B, the fat cell destroyer in Schisandra chinensis



In the fat cells, schisandrin-B did not increase the total amount of the hormone HSL, but schisandrin-B did increase the activity of the hormone. HSL plays a key role in the release of fatty acids from fat cells. HSL responds to ACTH and adrenaline, among other things.


Schisandrin-B, the fat cell destroyer in Schisandra chinensis



Animal study
Kwan injected diet-induced obese mice subcutaneously with schisandrin-B for 5 days. If the mice had been humans, they would have gained 0.03 grams per kilogram of body weight daily. Don't try this at home, folks.

The test animals lost fat.


Schisandra chinensis increases muscle strength by 8 percent



After the experiment, analyzes of adipose tissues showed that schisandrin-B in the subcutaneous fat had increased the activity of HSL.

Conclusion
"Our data shed light on the potential therapeutic use of schisandrin-B or Schisandra chinensis seed containing schisandrin-B for reducing obesity and hence the obesity-related comorbid conditions", writes Kwan.

Schisandra chinensis is interesting stuff. More coming soon.

Source:
Sci Rep. 2017 Aug 31;7(1):10266.

More:
Schisandra chinensis increases muscle strength by 8 percent 03.12.2019
Study: supplementation with schisandra maintains your muscle mass as you age 03.12.2019
Fructus Schisandrae inhibits muscle atrophy almost as well as oxymetholone 08.07.2015

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