Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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27.03.2018 |
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Animal study: SAM-e inhibits breast cancer
Supplements with S-adenosylmethionine [usually abbreviated to SAM-e] may prevent breast cancer or, if that disease is already present, inhibit the spread of the cancer over the body. This is evident from an animal study that researchers at McGill University in Canada published in Oncotarget.
SAM-e
Study
Three days after the implantation, the researchers started giving the mice SAM-e every day via the oral route. The human equivalent of the dose given that one group was given was about 200-300 milligrams of SAM-e per day, the other group received twice as much. A control group received no active substances.
Ten weeks after they had inserted the breast cancer cells, the researchers sacrificed the mice, and studied them.
Results
When the researchers looked at the functioning of these genes in women with breast cancer, they saw that the chance of metastasis was smaller for women whose genes were less active [A] than for women whose genes were fully active [B].
Conclusion
Careful...
"A major concern with the use of hypermethylating agents is the possible silencing of tumor suppressor genes through hypermethylation of promoter and other regulatory regions", the researchers acknowledge. "Such methylation could override the beneficial effect of S-adenosyl methionine."
"When we checked the expression of some of recognized tumor-suppressor genes in MDA-MB-231 tumors, there was no significant difference between control and SAM-treated groups. This also complements our previous genome-wide analyses in prostate cancer and osteosarcoma cell lines where the methylation effect of SAM was limited to cancer promoting genes for yet unknown reasons." [Br J Pharmacol. 2015 Jun;172(11):2769-81.] [Cancer Med. 2015 May;4(5):732-44.]
"More interestingly, database search using the panel of seven genes (MUC1, PLAU, FABP7, SPARC, HAS2, HAS3, SOX4) downregulated by SAM revealed that these genes are highly expressed in basal B-type breast cancer cell lines and higher expression of these genes significantly decreases the probability of distant metastasis-free survival in breast cancer patients." [Breast Cancer Res Treat. 2010 Oct;123(3):725-31.]
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