Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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02.11.2016 |
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This is the safe dose of nicotinamide riboside
Nicotinamide riboside
People in their forties and fifties who use nicotinamide riboside notice that they can once more train as hard as they did when they were fifteen years young. Athletes mostly use doses of 200-400 mg per day, which is more than the 100 or 125 mg that supplements makers advise. But are these safe doses?
Study
Results
And the researchers also noticed an increase in the concentration of white blood cells in the male rats at the 1000 mg dose. [Table] That can be a sign of tissue damage.
The researchers regard the 1000 mg dose as the lowest observed adverse effect level, or LOAEL: the intake at which a substance, as far as is known, starts to show side effects. The 300-mg dose is the no observed adverse effect level (NOAEL), the highest intake at which a substance is safe, as far as is known.
All the doses tested inhibited the increase in weight in the male lab animals. The researchers regard that as a desired effect of nicotinamide riboside rather than a side effect. After all, nicotinamide riboside supplementation improves the energy metabolism of muscle cells.
The researchers also went through other in-vitro and animal studies to see if they could find evidence that nicotinamide-riboside damages the genetic material. This was not the case.
Conclusion
"A tolerable upper intake level for human exposure to nicotinamide riboside is derived by application of a 100-fold safety factor to the no observed adverse effect level determined from this 90-day study; the tolerable upper intake level for nicotinamide riboside is 3 mg/kg/day or 180 mg/day, assuming a body weight of 60 kg."
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