Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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07.07.2018 |
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N-Acetylglucosamine accelerates the formation of muscle fibers
N-Acetylglucosamine
These supplements are meant to make joints healthier. Glucosamine and N-acetylglucosamine are the raw materials of hyaluronic acid, an important polymer in joints.
Researchers at the University of Laval in Canada suspect that N-acetylglucosamine also has a function in muscle development. When young muscle cells form muscle fibera, they use N-acetylglucosamine as glue to stick together. This could mean that supplementation with N-acetylglucosamine has a muscle-building effect.
Even outside of sport there is great interest in muscle building resources. Researchers like the Canadians are still feverishly looking for ways to slow down muscular diseases such as Duchenne's disease. And so the Canadians wondered: is N-acetylglucosamine such a drug?
In vitro study
The figure above suggests that the optimal concentration is perhaps 1 millimole. That is on the high side.
Below you can see the effect of exposure to 1 millimole N-acetylglucosamine for 72 hours.
Animal study
The supplementation had reduced muscle damage and made the muscles stronger. The researchers had stimulated the muscles electrically, and determined how much weight the muscles could get in motion.
Conclusion
"Although further study is essential to understanding the mechanism by which [...] N-acetylglucosamine mitigate[s] Duchenne muscular dystrophy and promote myogenesis, the present study indicates that using N-acetylglucosamine as a supplemental agent may present an interesting class of therapy for Duchenne muscular dystrophy, especially because the safety of this inexpensive monosaccharide is relatively established in humans."
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