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05.02.2021


How propolis blocks skin aging

How propolis blocks skin aging
Supplementation with propolis, the waxy substance with which bees build their nests, can slow down skin aging. South Korean biotechnologists come to this conclusion in an in vitro study published in Nutrients.

Study
The Koreans exposed human skin cells in test tubes to ultraviolet radiation, which damaged the collagen structures in the cells. UV radiation is the main cause of skin aging.

This increases the activity and production of the enzyme MMP1 in the cells. MMP1 breaks down collagen.

Results
Flu symptoms decreased equally in both groups. The differences shown below were not significant.

When the researchers exposed the cells to propolis extract [PPE], this reduced the activity of MMP1. The greater the concentration, the greater the effect.

Click on the figure below for a larger version.


How propolis blocks skin aging


How propolis blocks skin aging


The researchers repeated their experiments with pieces of human skin tissue and found the same effects. You can see that above.

Mechanism
MMP1 is activated by the enzyme phospho-inositide-3-kinase (PI3K). The researchers discovered that propolis blocks this phospho-inositide-3-kinase.

When they investigated which components of propolis caused this effect, it turned out that it was primarily the work of caffeic acid phenethyl ester, and second and third of quercetin and apigenin.

Click on the figure below for a larger version.


How propolis blocks skin aging


Source:
Nutrients. 2020 Dec 10;12(12):3790.

More:
This combination of astaxanthin and collagen keeps your skin young 17.11.2020
Edible mushrooms keep skin young 29.01.2020
Turkey tail extract keeps skin young 13.09.2018

Archives:
Propolis & Other Bee Stuff
Beautyceuticals


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If people with type 2 diabetes take 2 propolis capsules every day, their insulin sensitivity increases and their insulin levels drop.

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Researchers at New York University may now have discovered a new application for propolis.

Propolis versus CRP and TNF-alpha
This website wrote about the anti-inflammatory properties of ginger, Pycnogenol and Q10 in the near past. And perhaps supplementation with propolis is not such a bad idea either, we add today.