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22.10.2020


Do NO boosters inhibit the coronavirus?

Do NO boosters inhibit the coronavirus?
The NO boosters used by fitness fanatics and bodybuilders may protect against the dreaded coronavirus. This is suggested by an in vitro study published by the Swedish microbiologist Dario Akaberi, affiliated with the University of Uppsala, in Redox Biology.

Study
Akaberi released the coronavirus onto epithelial cells in his lab and then watched the virus multiply.

The researcher also exposed some cells to S-nitroso-N-acetylpenicillamine [SNAP] at the same time. S-nitroso-N-acetylpenicillamine is a NO donor. Akabari did not experiment with the substances that you can find in NO boosters, but with a substance that does the same.

Results
The higher the concentration of S-nitroso-N-acetylpenicillamine, the slower the coronavirus was able to multiply.


Do NO boosters inhibit the coronavirus?



Do NO boosters inhibit the coronavirus?


Each spot in the circles above is a cell that is no longer functioning properly due to the virus.

The figure below shows how NO boosters inhibit the virus. S-nitroso-N-acetylpenicillamine sabotages the protease enzyme. After having infected a cell, a virus needs protease to multiply itself.

NAP = non S-nitrosated N-acetylpenicillamine. Say: SNAP, but without an NO group to donate. A bit straightforward, but fine.


Do NO boosters inhibit the coronavirus?


Conclusion
"We conclude that NO may be applied for clinical use in the treatment of COVID-19 and other human coronavirus infections", the Swedes conclude.

Source:
Redox Biol. 2020 Sep 21;37:101734.

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