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29.01.2021


Who says cyanostane really works?

Who says cyanostane really works?
Cyanostane is a designer steroid, just like methasterone and epithiostanol. Developed decades ago by chemists who did not market it, rediscovered in the 21st century by small companies, who decided to commercialize it without further research. In itself a worrying practice that can be questioned, but in the case of cyanostane there is something more to it.

The claims
The companies that sell cyanostane claim that cyanostane is a very effective anabolic steroid. The main claim is that the ratio of anabolic:androgenic properties of cyanostane would be surprisingly high.


Who says cyanostane really works?


The studies
Anyone who wants to find out on which scientific research those claims are based will be surprised. If you search Julius Vida's standard work Androgens and Anabolic Agents for information about cyanostane, you will come across an anabolic steroid that looks like cyanostane, and has about the properties that the industry attributes to cyanostane.


Who says cyanostane really works?


However, this promising anabolicum is not cyanostane. Cyanostane can be described as 2-cyano-methyl-DHT, the anabolic above as 2-cyano-madol. Vida found the thing in an article that researchers at the American pharmaceutical company Syntex published in the Journal of Organic Chemistry in 1964. [J Org Chem 1964;29(11);3300-3.]

And in that article we come across cyanostane. Already on the first page.

It's steroid 1a. Tweaking this steroid, previously described in a 1960 paper in Chemistry & Industry (which we can't get a hold of), Syntex's research department made a number of delta-2 analogues that were quite active. According to their animal studies.


Who says cyanostane really works?


Who says cyanostane really works?


The new delta-2 analogues are "somewhat more androgenic" than testosterone and methyltestosterone, and "have a myotrophic activity which is severalfold that of the reference standards". Those reference standards are again testosterone and methyltestosterone.

Cyanostane itself doesn't do much, you can tell from the first sentences of the article.

Could it be that the creators of cyanostane confused two steroids?

Source:
J Org Chem 1964;29(11);3300-3.

More:
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