Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Creatine supplementation makes the immune system more resistant to infection
Neutrophils are the shock troops of the immune system. The cells eliminate pathogens such as viruses, bacteria and parasitic microorganisms through processes such as phagocytosis and netosis. Creatine supplementation kicks up this neutrophil activity. This is shown by a Japanese animal study.
Seven days before Saito infected the mice, the researcher started giving some of the test animals a daily amount of creatine. As long as the mice were alive, Saito would continue to do so. If the mice had been adult humans, they would have consumed roughly 4-6 grams of creatine per day.
When Saito took neutrophil immune cells from the mice's blood and studied them, he saw how creatine inhibits the spread of the immune system. Neutrophils are immune cells that can kill germs via, among other things, phagocytosis [uno] and netosis [duo]. Neutrophils use free radicals [ROS] in both processes.
Saito found that creatine supplementation increased free radical production by neutrophils and stimulated phagocytosis and netosis.
Of course, this is just an animal study. Human trials must first determine what creatine supplementation does to the human immune system, Saito thinks.