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18.11.2022

Combination Q10 and curcumin reduces migraines

Supplementation with a combination of Q10 and a well-absorbed form of curcumin makes the life of migraine sufferers less unpleasant. And the side effects of this approach? According to this trial, they are not existent.

Study
Researchers at Tehran University of Medical Sciences divided 100 people with regular migraine episodes into 4 groups.

For 8 weeks, one group received a placebo every day, a second group took 300 milligrams of Q10, a third group received 80 milligrams of curcumin in an improved absorbable form and a fourth group took both 300 milligrams of Q10 and 80 milligrams of curcumin.

The curcumin supplement that the Iranians used is shown below. It is called SinaCurcumin and contains curcumin molecules packaged in 20 nanometer nanomicelles.

If the subjects were already taking regular medication to prevent migraines, they continued to do so during the experiment.

Results
During the supplementation period, the number of episodes decreased in all groups, but in the supplementation groups the decrease was a bit more convincing. Supplementation with both curcumin and Q10 works significantly better than administration of a placebo.

The researchers could not find significant differences between the groups regarding the severity and duration of the episodes, although the table below suggests that the supplement groups fared better than the placebo group.

Click on the tables for a larger version.

The researchers had the subjects fill out three questionnaires that have been developed to measure the quality of life of migraine and headache patients. The table above shows that the scores of the subjects in the curcumin + Q10 group were significantly better than those of the other groups.

As far as the researchers could tell, supplementation had no side effects.

Mechanism
Both Q10 and curcumin inhibit inflammatory reactions. Because inflammatory reactions play a role during migraine attacks, the Iranians suspect that the combined anti-inflammatory effect of Q10 and curcumin can alleviate migraines.

Source:
Nutr Neurosci. 2021 Apr;24(4):317-26.

More:
Q10 and L-carnitine effective against migraine 13.05.2019
Magnesium, vitamin B2 and co-enzyme Q10 combo soothes migraine 26.09.2015

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Headache & Migraine
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