Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
Arg-His-Trp | A tripeptide and a beta-2 agonist
Researchers from India have discovered a tripeptide that may be of great interest to manufacturers of supplements for bodybuilders. According to in vitro and in silico studies, arginyl-histidyl-tryptophan is just as much of a full blown beta-2 agonist as clenbuterol.
Chandore discovered the peptide in cells he cultured in vitro. The cells grew in fetal bovine serum. Fetal bovine serum is the blood of unborn calves, which is collected in slaughterhouses. Molecular scientists use it to grow cells, for which purpose fetal bovine serum is suitable as it contains many growth factors. Whether there are also minuscule bioactive proteins such as arginyl-histidyl-tryptophan in fetal bovine serum has never been investigated before.
The peptide came from the calf serum, Chandore discovered. It can apparently survive in the bloodstream.
The way in which Arg-His-Trp attaches to this receptor is quite robust. The biological effect of Arg-His-Trp should, again according to Chandore's calculations, be comparable to that of pharmacological beta-2 agonists.
Putting everything together
Tripeptides are generally well absorbed. Because Arg-His-Trp probably also survives well in the bloodstream, the bioavailability should be perfectly fine. Toxic side effects such as liver and kidney damage are unlikely.
Beta-2 agonists help fight asthma and increase oxygen uptake. They also have a performance-enhancing effect and are suitable for improving body composition. They help to reduce fat mass while retaining muscle mass.
Argistropine - a trade name for Arg-His-Trp that we spontaneously come up with - could be a damn interesting sports supplement.