Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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28.01.2018 |
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Animal study: anti-cancer effect EPA and DHA 8 times greater than that of ALA
Study
The researchers divided the mice into 4 groups. Each group received feed with a different fatty acid composition.
10% SF 10% of the feed is safflower oil. Safflower oil mainly contains omega-6 fatty acids. There are indications that a diet with too much of this type of fatty acids increases the risk of cancer and a number of other chronic diseases.
3% FS 7% of the feed is safflower oil and 3% is flaxseed oil. Flax seed oil containts the omega-3 fatty acid ALA. A diet with relatively large amounts of that fatty acid may protect against breast cancer - and a number of other chronic diseases.
10% FS 10% of the feed is flaxseed oil.
3% FO 7% of the feed is safflower oil, 3% is fish oil. Fish oil contains the omega-3 fatty acids DHA and EPA. Those fatty acids are more active in the body than ALA. Converted to humans, the mice in this group received about as much fish fatty acids as Japanese. They eat oily fish 2 to 3 times a week.
Results
The figure above shows that 10% FS and 3% FO reduced the total tumor volume in the mice.
Mechanism
Conclusion
"The mice were exposed to the different omega-3s even before tumours developed, which allowed us to compare how effective the fatty acids are at prevention. It's known that EPA and DHA can inhibit breast tumour growth, but no one has looked directly at how effective these omega-3s are compared to ALA."
"It seems EPA and DHA are more effective at this. In North America, we don't get enough omega-3s from seafood, so there lies an opportunity to improve our diet and help prevent the risk of breast cancer."
"Seeing the significant benefits omega-3s can have in combatting a highly aggressive form of breast cancer means omega-3s will likely be beneficial for other types of cancer."
"Furthermore, it can be estimated that on a per molecule basis, the relative tumor inhibitory effect of plant derived ALA was approximately 1/8 as potent as marine-based n-3 PUFA containing EPA and DHA", the Canadians wrote.
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