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25.09.2021


Move aside, TA-65! Make way for 08AGTLF!

Isn't writing for Ergo-Log a lot of fun? No other medium allows you to put such a weird headline above your article. Only Ergo-Log readers know that TA-65 is an incredibly expensive longevity supplement that is supposed to increase telomerase activity, thus extending life. What 08AGTLF exactly is, the readers may not yet know. But they are curious about it.


Move aside, TA-65! Make way for 08AGTLF!


What is 08AGTLF?
Well, the in vitro study that Greek professor Dimitris Tsoukalas published in 2019 in Molecular Medicine Reports does not answer that question. In this study, Tsoukalas exposed human blood cells to a number of possible longeceuticals and then determined whether the substances in question increased the activity of telomerase in the cells.

Telomerase is the enzyme that lengthens telomeres in DNA. In this way, telomerase could slow down aging.

Telomeres are located at the ends of the chromosomes. During the aging process, those telomeres shorten. The faster the telomeres shorten, the faster the biological aging process. And according to a number of anti-aging researchers, the opposite may be also true. Cells rejuvenate as telomeres lengthen again.

Results
One of the substances the Greeks tested was cycloastragenol, a component of Astragalus membranaceus and the active ingredient in the cult supplement TA-65. Cycloastragenol did indeed activate telomerase, but the effect was not overwhelming.

One longeceutical that did have an impressive effect on telomerase was an extract of Centella asiatica, also known as Gotu Kola, which the Greeks call 08AGTLF.


Move aside, TA-65! Make way for 08AGTLF!


Results
Nutrient 4 was a blend of longeceuticals contained in a commercially available supplement. If you want to know more about it, take a look at Tsoukalas' full publication. The link can be found at the bottom of this article.

Again: what is 08AGTLF?
The only thing the researchers want to say about 08AGTLF is that they bought the extract in question from ApexBio. [apexbt.com] On the ApexBio website you can read that 08AGTLF is madecassic acid. Maybe we'll hear more about this substance soon.


Move aside, TA-65! Make way for 08AGTLF!


Conclusion
"The aim of this study was to identify natural compounds that significantly increase telomerase activation, and may lead to a longer life expectancy and healthy aging", summarizes Tsoukalas.

"08AGTLF, containing Centella asiatica extract, seems to be such a natural compound with a strong effect on telomerase activity that remains to be validated with future research based on independent randomized controlled studies investigating the underlying mechanisms. Importantly, future intervention studies on humans are warranted to examine its effect on telomere length, aging and human health."

Source:
Mol Med Rep. 2019 Oct;20(4):3701-8.

More:
Endurance training and interval training activate telomerase 04.12.2018
More yoga, more telomerase 30.06.2018
Meditate for more telomerase 13.05.2017

Archives:
Longevity


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