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25.07.2019

The modest fat loss effect of chlorogenic acid

Daily supplementation with 300 milligrams of chlorogenic acids - the bioactive substances in Green Coffee Bean extract - can slightly reduce the amount of belly fat. Researchers from the Japanese Kao Corporation write this in Nutrients. The effect that the Japanese report is significantly smaller than in previously published studies. And much more credible.

Study
The researchers divided 142 healthy but overweight adults aged 20-65 into 2 groups. All groups drank a cup of instant coffee every day for 12 weeks. One group received regular instant coffee, the other coffee to which the researchers had added around 300 milligrams of chlorogenic acid analogues.

Besides caffeine, chlorogenic acid analogues are the most important bioactive constituents of coffee. They are also the most important ingredients in the Green Coffee Bean extracts that you find in all kinds of weight loss supplements, and which, according to some fraudulent studies, could lead to 8 kilos of weight loss.

Results
The subjects who consumed extra chlorogenic acids lost a little of their BMI and became a few millimeters slimmer in their waist.

Click on the figures below for a larger version.

According to abdominal scans, the subjects in the experimental group had slightly less belly fat after the trial. This effect was statistically stronger than the one above, but still modest.

Mechanism
The absence of sensational results did not prevent the authors from speculating about the mechanism by which chlorogenic acids may cause fat loss. "The mechanism underlying the effect of instant coffee containing high amounts of chlorogenic acids [...] on decreasing abdominal visceral fat might involve both increased energy expenditure and increased fat burning", they write.

"According to a human clinical trial comparing daily consumption of roasted coffee containing 359 mg chlorogenic acids and placebo coffee for one week, repeated consumption of chlorogenic acids decreased the respiratory quotient and increased oxygen consumption, which means that both energy expenditure and fat oxidation were increased." [J. Health. Sci. 2010, 56, 745-51.]

"Furthermore, feeding green coffee bean extract containing chlorogenic acids to mice with diet-induced obesity affects body fat accumulation, with a dose-dependent inhibition of the increase in body weight and accumulation of visceral fat and liver fat." [Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E122-33.]

"In addition, analysis of the expression of energy metabolism-related genes in the liver revealed significantly decreased messenger RNA expression of stearoyl-CoA desaturase 1, acetyl-CoA carboxylase 1 (ACC1), and ACC2, which are involved in fatty-acid oxidation, after mice were administered green coffee bean extract containing chlorogenic acids for two weeks."

"Decreased expression of stearoyl-CoA desaturase 1 and ACC1, which are involved in fatty-acid synthesis, promotes energy expenditure, and decreased ACC2 expression increases fatty-acid oxidation in the mitochondria through the reduced production of malonyl CoA, which inhibits carnitine palmitoyltransferase 1."

Conclusion
"Consumption of high-chlorogenic acids coffee for 12 weeks by overweight adults might lower visceral fat area, total abdominal fat area, BMI, and waist circumference", conclude the researchers.

Source:
Nutrients. 2019 Jul 16;11(7).

More:
Slimming effect of Green Coffee Bean: study was fake 14.11.2014
Green Coffee Bean extract makes weight loss diet more effective 18.09.2013

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