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How Pycnogenol slows aging and reduces the risk of chronic diseases

Why Pycnogenol slows aging and reduces the risk of chronic diseases
If you want to live a long and healthy life, you'd better keep the concentration of inflammatory proteins like TNF-alpha and CRP in your body low. An anti-inflammatory lifestyle not only inhibits the aging process, but also protects against cardiovascular diseases and cancer. Iranian nutritional scientists from Shahid Beheshti University, published a meta-study showing that supplementation with Pycnogenol fits perfectly in such an anti-inflammatory lifestyle.

In biomedical literature, the researchers traced 5 trials in which subjects had received Pycnogenol, and where the effect on the CRP level was measured. A total of 324 people had participated in these trials.

The researchers aggregated the results of the trials and analyzed them again.

Supplementation with Pycnogenol resulted in a significant reduction of the CRP level. No megadosis was needed for this, the figure below shows. The trials with a dose of less than 150 milligrams of Pycnogenol per day resulted in even better results than the trials with a higher dose.

Click on the figure for a larger version.

Why Pycnogenol slows aging and reduces the risk of chronic diseases

Pycnogenol seems to be working especially in people over 55, the researchers discovered when they analyzed their data.

Pycnogenol occasionally had side effects. Nausea was one of them. But that side effect can be solved by taking Pycnogenol with a meal, according to the studies.

"Present meta-analysis pooled results from randomized clinical trials about the effect of Pycnogenol supplementation on CRP level", the researchers summarize. "The results showed Pycnogenol consumption can decrease the level of CRP and has an anti-inflammatory effect Larger randomize clinical trial with long duration of treatment is needed to confirm the anti-inflammatory effect or Pycnogenol."

Clin Nutr Res. 2018 Apr;7(2):117-25.

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