Propolis versus CRP and TNF-alpha
A chronically increased activity of the inflammatory cytokines CRP and TNF-alpha increases the risk of premature death and unpleasantly many chronic diseases. What helps against that? This website wrote about the anti-inflammatory properties of ginger, Pycnogenol and Q10 in the near past. And perhaps supplementation with propolis is not such a bad idea either, we add today.
Complementary Therapies in Medicine will soon publish a meta-study by Mohammad Jalali, a nutritional scientist from Shiraz University of Medical Sciences in Iran. Jalali traced six trials in the scientific literature in which researchers tested the effects of propolis on subjects, swept the results together and analyzed them again.
In the studies Jalali selected, the daily dose of propolis ranged from 66 to 1500 milligrams per day. The duration of the supplement varied from 8 to 104 weeks.
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Propolis is a bee product. It is the glue that bees use to build their nests. The main bioactive substances in propolis are phenols. A prominent one is caffeic acid phenethyl ester [CAPE], an analogue of caffeic acid with a particularly high bioavailability. In fundamental studies, caffeic acid phenethyl ester inhibits cancer cells, aging processes, free radical activity and inflammatory reactions.
Propolis supplementation decreased both CRP and TNF-alpha activity. Looking at the individual studies may give you the impression that the positive effect of propolis is stronger the higher the dose administered, and the longer the duration of the supplementation.
"More trials about propolis supplementation on different groups and various inflammatory markers are warranted to better elucidate the anti-inflammatory properties and mechanism of action of propolis", writes Jalali.
"On the other hand, different types of propolis from various geographical regions might express different properties as the bees might feed from many various plants and this needs further investigation."
Complement Ther Med. 2020 May;50:102380.
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