Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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13.05.2015 |
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Combination of Maca, Cat's Claw, Boswellia serrata and leucine protects joints
A supplement containing leucine and extracts of Cat's Claw [Uncaria tomentosa], Boswellia serrata and Maca [Lepidium meyenii] may protect joints against osteoarthritis and overuse. This is suggested by an in-vitro study that rheumatologists at Case Western Reserve University in the US published in BMC Complementary and Alternative Medicine.
Flexsure
The 2011 study was partly funded by the American government – in the form of the National Institute of Health/National Center for Complementary and Alternative Medicine.
Maca, Cat's Claw and cartilage
Plus Boswellia serrate and leucine
And you probably know what's coming next... The researchers decided to see what would happen if they exposed cartilage cells to a combination of leucine and extracts of Boswellia serrata, Maca and Cat's Claw.
Results
When cartilage disintegrates the activity of the enzyme inducible nitric oxide synthase [iNOS] increases. This enzyme produces nitric oxide. Interleukine 1-beta boosted the concentration of inducible nitric oxide synthase and nitric oxide, but it didn't do this in the presence of leucine, Boswellia serrata, Maca and Cat's Claw.
Interleukin 1-beta activates the proteases MMP-9 and MMP13 in cartilage – but doesn't do so, or does so less when leucine, Boswellia serrata, MMP and Cat's Claw are present.
Healthy cartilage cells produce aggrecan [ACAN, a sugar protein that absorbs shocks in joints] and type-II collagen [COL2A1, the basic building block of cartilage]. Interleukin 1-beta reduces the production of both aggrecan and type-II collagen, but doesn't do so or does so less in the presence of leucine, Boswellia serrata, Maca and Cat's Claw.
Conclusion
Source:
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