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Ergo-Log

22.07.2009


Testosterone patch makes women more muscular

Women with low testosterone levels who attach an Intrinsa testosterone plaster to their body become more muscled and feel better, according to a study by researchers at Massachusetts General Hospital. They tested the plasters for a year on 25 women with hormonal abnormalities.

Intrinsa is made by Procter & Gamble. The women stuck two plasters on their abdomen and changed them twice a week. The plasters provided the women with 150 micrograms of testosterone [structure shown here] every day. This dose is only six percent of the amount of testosterone provided to men when they use this kind of patch.

The researchers did a trial on fifty women between the ages of 19 and 50 whose sexual organs and adrenals no longer produced testosterone because their hormone glands in the brain were not functioning properly. Their free testosterone level was 0.5 – 0.6 pg/ml. Normal values are 1.1 – 6.3 pg/ml. The testosterone level of the 25 women who were given Intrinsa plasters returned to normal, as the figure below shows. The other half of the women were given a placebo.


Testosterone patch makes women more muscular


What the figure doesn't tell is that a doctor regularly checked the women's hormone levels. Nine of the women had to halve their dose because their testosterone level rose too high. That's one in three of the test subjects.

The Intrinsa users' bone mass also increased, and the women using the Intrinsa plasters reported feeling better and an improvement in their sex lives. The figure below is based on the answers the women gave to the standardised questions the researchers asked.


Testosterone patch makes women more muscular


And, last but not least, the women's fat free mass increased, part of which was muscle mass.


Testosterone patch makes women more muscular


The women experienced hardly any side effects. The cholesterol levels of a few rose, but only by minimal amount. The most noticeable side effect was that eight women developed acne, the researchers reported. But when we, the nitpickers from this gossip site, got hold of the table of side effects, we noticed one that women might find interesting, even though it's not statistically significant. Seven women who used the Intrinsa plasters developed hirsutism.


Testosterone patch makes women more muscular


The study was not paid for by the manufacturer of Intrinsa, Procter & Gamble. But the first author of the article and the research leader did receive occasional 'presents' from Procter & Gamble. You know the kind of thing, probably completely innocent: a diary, a mouse mat, a ballpoint pen. That kind of thing.

Source:
J Clin Endocrinol Metab. 2006 May;91(5):1683-90.

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