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06.03.2018

Eating too much? The combination of grape extract and physical activity offers more protection than physical activity alone

You consume too many calories, and therefore you are fat and out of shape. The best medicine? More exercise, most scientists will say. A solid advice, but it will be even more effective if you also supplement with grape extract. French researchers came to this conclusion when they did some experiments with rats. The human equivalent of the amount of polyphenols that the researchers used fits in one or two capsules...

Study
The researchers divided young rats into 4 groups.

HF During the 8 weeks that the experiment lasted, these animals received high-caloric feed with extra fat. The animals thereby became fatter, and developed insulin resistance.

PP The rats in this group also received high-fat feed, and also received grape extract every day via their drinking water. If the rats had been adult humans, the administered dose would have amounted to about 500-700 milligrams of extract per day. That extract consisted for 64 percent of polyphenols.

EXO The rats in this group were fattened, and also had to run an hour on a treadmill for 5 days a week.

EXOPP These rats were fattened, had to run and was supplemented with grape polyphenols.

Results
Supplementation with grape extract made the test animals slimmer; so did physical exercise.

Supplementation had a positive effect on muscle mass, possibly because the polyphenols increased the sensitivity to insulin.

At the end of the supplementation period the researchers let the rats run to exhuastion, and discovered that the animals that had trained and had received grape polyphenols performed much better than the other animals.

In the cells of the rats in the latter group, the researchers found more active AMPK. That enzyme becomes active through fasting, caloric restriction, movement and exposure to a lot of plant compounds. AMPK makes cells more sensitive to insulin, stimulates fat burning and activates repair processes.

In the muscles and liver of the rats who had trained and had grape polyphenols, the researchers did indeed find less fat, and more glycogen. This indicates that the combination of polyphenols and exercise stimulates the burning of fat more than exercise alone.

Conclusion
"In conclusion, our study demonstrates that, in high-fat diet-induced obese rats, the combination of exercise and grape polyphenols supplementation counteracts anthropometric and metabolic impairments and increases endurance capacity, probably via enhancement in lipid oxidation and reduction in glycogen utilization", the researchers write.

"Our data highlight that, when obesity and insulin resistance are already developed, the combination of nutritional grape polyphenols supplementation and exercise have synergistic metabolic effects, underlining the importance of both dietary and physical training recommendations in insulin resistance condition."

Source:
Sci Rep. 2018 Feb 13;8(1):2885.

More:
Grape Seed Extract during menopause: fewer hot flushes, more muscle and better sleep 12.08.2015
Grape Seed Extract keeps big eaters' weight down 11.12.2012

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