Cordycepin from Cordyceps militaris rejuvenates testes
In Asia, but increasingly also in Western countries, men use supplements with extracts from the mushrooms Cordyceps sinensis and Cordyceps militaris. These products should increase the production of testosterone. According to an animal study that researcher from Sejong University in South Korea published in Nutrients, those supplements might work. For middle-aged and older men.
The researchers gave male adult rats, one year old, a dose of cordycepin [COR20] every day for six months via the oral route. The researchers had extracted the compound from Cordyceps militaris. After this six-month period, the researchers studied the testes of the animals. They compared the organs with the testes of young [YC] and equally old [AC] rats who had not received cordycepin.
The data below shows the rats that received the highest dose. The human equivalent of that dose is approximately 220 milligrams of cordycepin per day. Indeed, that's quite an amount of mushrooms. Fortunately, research suggests that lower doses may be effective as well.
The researchers found fewer androgen receptors [AR], fewer FSH receptors [FSHR] and fewer LH receptors [LHR] in the testes cells of the old animals [AC] than in the cells of the young animals [YC]. This implies that the cells in the testes become less sensitive to the growth stimulus of FSH and LH.
However, administration of cordycepin [COR-20] reduced the aging-induced decrease in receptors.
Aging reduced the concentration of endogenous antioxidant enzymes in the testes. Cordycepin supplementation completely abolished this decrease.
Aging finally reduced the amount of the anti-aging enzyme SIRT1. Cordycepin put a stop to this. You can see this below. The bigger the blob, the more SIRT1.
"From the perspective of cellular mechanism, cordycepin appears to be involved in ameliorating aging-induced gene expression associated with testicular function, particularly those related to spermatogenesis, antioxidant defense, [and] acetylation (SIRT1) [...]", write the Koreans.
"The present study suggests that cordycepin may provide an excellent nutritional potential [...] in ameliorating age-related male sexual dysfunction."
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