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28.01.2020


Bifidobacterium breve B-3 accelerates body fat breakdown in human study

Bifidobacterium breve B-3 accelerates body fat breakdown in human study
Last week we wrote about an animal study in which supplementation with the probiotic Bifidobacterium breve B-3 made muscles bigger and stronger. Researchers from Morinaga, Japan, published a study in 2018 in which they gave the same bacterium to humans. Without the test subjects changing their way of life, they became a little leaner.

Study
The researchers divided 81 healthy but somewhat plump test subjects into 2 groups. For 12 weeks one group took 2 capsules without active substances every day, while the other group took 2 capsules daily with 10-10 CFUs of Bifidobacterium breve B-3. The test subjects took the capsules during a meal.

Results
Bifidobacterium breve B-3 reduced the fat mass and the fat percentage. Supplementation with the probiotic had no effect on body weight, but did reduce the abdominal circumference of the subjects.


Bifidobacterium breve B-3 accelerates body fat breakdown in human study


Bifidobacterium breve B-3 accelerates body fat breakdown in human study


The decrease in abdominal circumference was the result of a decreased amount of abdominal fat, you see at the bottom left. However, this decrease was not accompanied by a decrease in muscle mass, the figure in the lower right said. The muscle mass even seemed to increase slightly in the experimental group.


Bifidobacterium breve B-3 accelerates body fat breakdown in human study


Side effects
Supplementation with Bifidobacterium breve B-3 did not have any negative side effects. However, the amount of triglycerides in the blood of the test subjects in the experimental group decreased slightly. [Table] That's positive.

This decrease is probably a direct consequence of the suspected mechanism of action of Bifidobacterium breve B-3. The researchers think that the bacteria stimulate the activity of Cyp4a enzymes in the liver. Cyp4a enzymes are involved in the oxidation of fatty acids. [Biochem Pharmacol. 2008;75(12):2263-75.]

Conclusion
"The present study demonstrated that daily consumption of Bifidobacterium breve B-3 at a dose of 20 billion CFU/day for 12 weeks exerted significant reducing effects on body fat in healthy pre-obese adults without any adverse effects", the researchers summarize.

"Bifidobacterium breve B-3 [...] may be useful for preventing body fat accumulation and related metabolic disorders in pre-obese individuals."

Source:
Biosci Microbiota Food Health. 2018;37(3):67-75.

More:
Bifidobacterium breve B3, a probiotic for your muscles 21.01.2020

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