Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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15.12.2019 |
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How avocatin-B, the FAO inhibitor in avocado, protects against type 2 diabetes
Avocados contain fatty acids that you will not find in other foods. Avocatin-B, chemists call those fatty acids. According to Canadian researchers, avocatin-B can prevent overweight and obese people from getting diabetes. Next year the first products with avocatin-B should hit the market.
Avocatin-B
However, most avocadene and avocadyne molecules in avocados are attached to other molecules. If you include those bound fatty acids, you will come to nearly 180 milligrams of avocatin-B per avocado. It is not clear whether people can absorb bound avocatin-B.
Spagnulo and his colleagues have been studying avocatin-B for several years. In previous publications they described how avocatin-B sabotages the oxidation of fatty acids in the mitochondria of leukemia cells, and as a result causes the mitochondria to produce so many free radicals that the leukemia cells die. [Cancer Res. 2015;75(12):2478-88.]
Avocatin-B is therefore a fatty acid oxidation [FAO] inhibitor. For the doping experts among us: the mechanism of action of avocatin-B is reminiscent of the Russian doping agent meldonium. Although we do not want to admit that avocatin-B is interesting for athletes, we would appreciate it if some of our academic readers on the Asian continent would be willing to test the anti-fatigue and ergogenic properties of avocatin-B in a relevant animal model.
Animal study
After week 8, the researchers divided the fattened mice into two groups. The animals in one group received a placebo twice a week for oral administration [HFD] for 5 weeks, the animals in the second group received an oral dose of avocatin B [Avo-HFD] twice a week.
If the mice were adult humans, they would have received a dose of 600-800 milligrams of avocatin B twice a week.
Results
Human research
Although the subjects were lean, the researchers nevertheless saw a - not significant - trend that supplementation reduced body weight.
Serious side effects did not occur. A few test subjects who used a high dose of avocatin B did get a skin rash, which disappeared within a week after the test subjects stopped taking the supplement.
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