Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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05.08.2009 |
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Grape Seed Extract inhibits aromatase
Supplements containing Grape Seed Extract (GSE) may well lower estradiol levels. This would make GSE an interesting supplement for athletes who want to lose weight faster or just tone up their body a bit more. Cancer researchers at the Beckman Research Institute in California demonstrated the anti-estrogenic effect of GSE in tests they did on cells.
Lowering aromatase
This is of interest to cancer researchers because it's estradiol that's responsible fro the growth of many forms of breast cancer. Tumours often make their own aromatase.
So it would be even better if there were naturally occurring substances that not only deactivate aromatase, but also prevent cells from making aromatase in the first place. Which of course leads to the 64 million dollar question: is GSE capable of doing this?
To answer this question, the researchers first looked at whether GSE indeed inhibits aromatase. They put increasing concentrations of the extract in test tubes with aromatase producing cells, and then measured how much estradiol was produced. The figure below shows that the more GSE there was in a test tube, the less estradiol was produced.
Mechanism
The researchers added GSE to cells and then looked at whether the cells could still read all bits of the DNA. They noticed that the extract made the cell miss bits.
When the researchers looked at why that happened, they saw that GSE sabotages two transcription factors that the cell needs to read the gene for aromatase.
If you compare DNA with an old-fashioned LP [long playing record for those of you under 40] and the rest of the cell with an equally old-fashioned record player, then a transcription factor is the needle that you place on the record to transcribe it. The metaphor doesn't quite work, because a cell has lots of transcription factors and a record player only one, but you get the idea.
Glucocorticoid receptor
Lots of phenols have a cortisol inhibiting effect. Quercetin is one of these. Natural athletes who've experimented with mega-doses of quercetin (500 to 1500 mg per day) notice that they lose some abdominal fat, according to Ergo-Log sources.
In vitro, not in vivo
In the case of GSE, however, the scenario might not be too bad. The body does actually absorb most substances in GSE pretty well.
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