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Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "
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07.12.2010 |
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3N-GH lasts 24 times as long as regular growth hormone
Design
Amgen produced Aranesp by attaching the EPO molecule to sugar groups. The result was an EPO variation that lasts longer in the body. The sugar groups get in the way of enzymes that break down the EPO hormone.
So we can do that too with growth hormone, thought the researchers at Novo Nordisk.
Human growth hormone is a long chain of 191 amino acids. The researchers made genetically modified cells attach a sugar chain on the amino acids 93, 98, 99 and 104. Because the modified cells attached an amino acid to 98 or 99, but not to both, the new analogue had 3 new sugar chains.
#N-GH
The researchers injected their new preparation into rats that were no longer able to synthesise their own growth hormone. Because the half-life of 3N-GH was extended by a factor 24 compared with regular growth hormone, the animals grew much faster from a one-time injection of 15 nanomols 3N-GH than from daily injections of 10 nanomols.
This is because 3N-GH led to a long-term rise in IGF-1. GH stimulates growth mainly by raising the IGF-1 level.
Market introduction?
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