ergo-log.com

Definition: "An ergogenic aid is any substance or phenomenon that enhances performance "

about us

/

contact

/

07.12.2010


3N-GH lasts 24 times as long as regular growth hormone

Researchers at Novo Nordisk are working on a new generation of growth hormone analogues, which users have to inject far less frequently than the growth hormone currently available on the market. According to a study published in Endocrinology, the pharmaceutical company has a hormone that lasts 24 times as long in the body as regular growth hormone does.

The biochemical trick that Novo Nordisk, maker of NovoPen with which chemical athletes will be familiar, is using has already been used by the pharmaceutical company Amgen. Amgen produced Aranesp by attaching the EPO molecule to sugar groups. The result was an EPO variation that lasts longer in the body. The sugar groups get in the way of enzymes that break down the EPO hormone.

So we can do that too with growth hormone, thought the researchers at Novo Nordisk. Human growth hormone is a long chain of 191 amino acids. The researchers made genetically modified cells attach a sugar chain on the amino acids 93, 98, 99 and 104. Because the modified cells attached an amino acid to 98 or 99, but not to both, the new analogue had 3 new sugar chains.


3N-GH lasts 24 times as long as regular growth hormone


The researchers call their new compound 3N-GH. The N stands for N-glycosylation: the chemical term for attaching a glucose-based sugar chain to an N atom on a side chain of arginine or asparagine.

The researchers injected their new preparation into rats that were no longer able to synthesise their own growth hormone. Because the half-life of 3N-GH was extended by a factor 24 compared with regular growth hormone, the animals grew much faster from a one-time injection of 15 nanomols 3N-GH than from daily injections of 10 nanomols.


3N-GH lasts 24 times as long as regular growth hormone

3N-GH lasts 24 times as long as regular growth hormone


This is because 3N-GH led to a long-term rise in IGF-1. GH stimulates growth mainly by raising the IGF-1 level.

It'll be a while before 3N-GH makes it onto the market though. Reading between the lines of the article, the researchers have not yet perfected the production process.

Source:
Endocrinology. 2010 Nov; 151(11): 5326-36.

More:
Strong stuff, the new SARM from Radius 19.10.2010
Merck's new anabolic steroid: MK-0773 02.07.2010
Bottle of S4 costs $170 online 23.11.2009