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15.08.2017

Q10 and selenium supplementation raises IGF-1 level by 20 percent

Supplementation with selenium - a trace element that most westerners don't consume enough of - and the co-enzyme Q10 boosts the IGF-1 level by almost twenty percent. Swedish researchers at the University of Linköping write about this in PLoS One. The doses that the researchers needed were modest but the supplementation period was long...

Study
The researchers gave 215 elderly Swedes –-their average age was 76 - 200 mg Q10 and 200 mcg selenium every day for four years - or a placebo. The supplements that the researchers used came from Pharma Nord. That company was one of the financial sponsors of the study.

Just before starting supplementation and at the end of the supplementation period the researchers measured the concentration of IGF-1 in the participants' blood.

Results
At the end of the four years the IGF-1 level in the placebo group [active group 0; blue line] had gone down slightly. In the supplementation group [active group 1; red line] the IGF-1 level had increased from 154 mcg IGF-1 per litre to 183 mcg per litre. The increase represented a statistically significant effect.

Conclusion
"IGF-1 has important functions in both cell growth and metabolism, but also in inflammation and antioxidative defense," wrote the researchers. "A decrease in IGF-1 has been reported with increased age, and also in advanced cardiovascular disease."

"From our studies on an elderly healthy Swedish population, we have reported in previous publications that more than 90 percent had suboptimal selenium status. [PLoS One. 2016; 11(7):e0157541.] The present evaluation shows that intervention with selenium and coenzyme Q10 resulted in increased levels of IGF1."

Source:
PLoS One. 2017 Jun 13;12(6):e0178614.

More:
Colostrum packed with IGF-1, WADA advises against use 04.08.2017
Pleurotus eryngii: more growth hormone, IGF-1 and testosterone 19.09.2012
Dried prunes boost IGF-1 levels in humans 24.06.2012

Archives:
Growth Hormone & IGF-1
Selenium
Minerals
Q10

Combination of selenium and NAC raises testosterone levels Trial with nearly five hundred men.	Metastudy: selenium helps prevent prostate cancer Study by nutritionists at the University of East Anglia, who compared and reanalysed data from 12 epidemiological studies of more than 13,000 men.	Three amino acids and selenium supplementation prevents age-related muscle breakdown Supplementation with selenium and the amino acids cystine, glycine and glutamine prevents age-related muscle breakdown in lab animals. Study with hmm-factor.